Petersen R, Mikkelsen S, Thomsen O F
Department of Occupational Medicine, Glostrup Hospital, University of Copenhagen, Denmark.
Occup Environ Med. 1994 Apr;51(4):259-61. doi: 10.1136/oem.51.4.259.
Chromium is nephrotoxic in experimental animals. In subjects with acute chromium intoxication acute nephritis has been reported and renal function has been affected in chromium exposed workers with a high urinary chromium concentration. Chronic kidney disease after long term occupational exposure to chromium has, however, not been reported previously. A case report is presented concerning a 48 year old man who was diagnosed with chronic interstitial nephropathy. He had worked for nine years as a plasma cutter of stainless steel and had thereby been exposed to smoke containing chromium. At the time of diagnosis his blood chromium concentration was seven times higher and his urinary chromium concentration six times higher than reference values. Taking into account the nephrotoxicity of chromium and the high chromium burden of this patient it is considered likely that his exposure to smoke from plasma cutting of stainless steel was the cause of his chronic interstitial nephropathy.
铬在实验动物中具有肾毒性。在急性铬中毒患者中，已有急性肾炎的报告，并且在尿铬浓度高的接触铬的工人中，肾功能也受到了影响。然而，此前尚未有长期职业接触铬后发生慢性肾病的报告。本文报告了一例48岁男性被诊断为慢性间质性肾病的病例。他从事不锈钢等离子切割工作九年，因此接触到含铬烟雾。诊断时，他的血铬浓度比参考值高七倍，尿铬浓度比参考值高六倍。考虑到铬的肾毒性以及该患者的高铬负荷，认为他接触不锈钢等离子切割产生的烟雾很可能是其慢性间质性肾病的病因。
