Burry H C, Dieppe P A
Br Med J. 1976 Jul 3;2(6026):16-7. doi: 10.1136/bmj.2.6026.16.
A prospective study of nine patients with rheumatoid arthritis and 11 healthy volunteers who started salicylate treatment showed that in 18 of the 20 subjects creatinine clearance values fell the average being 25%. Serum creatinine concentration was increased by an average of 38%, although blood urea levels were unchanged. Since 51Cr-edetic acid clearance tests performed at the same time in 12 of the subjects were not affected, the fall in creatinine clearance was probably not due to impaired glomerular function, and salicylate ingestion may therefore invalidate the creatinine clearance test as an index of glomerular filtration rate. It is clearly important to inquire into the patient's analgesic comsumption when using the creatinine clearance test to assess glomerular function.
一项针对9名类风湿性关节炎患者和11名开始水杨酸盐治疗的健康志愿者的前瞻性研究表明，在20名受试者中，有18人的肌酐清除率值下降，平均下降25%。血清肌酐浓度平均升高38%，尽管血尿素水平未变。由于同时对12名受试者进行的51Cr-依地酸清除率测试未受影响，肌酐清除率下降可能并非由于肾小球功能受损，因此摄入水杨酸盐可能会使肌酐清除率测试作为肾小球滤过率指标无效。在使用肌酐清除率测试评估肾小球功能时，询问患者的止痛药物服用情况显然很重要。
