Sogawa S, Nihro Y, Ueda H, Miki T, Matsumoto H, Satoh T
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Biol Pharm Bull. 1994 Feb;17(2):251-6. doi: 10.1248/bpb.17.251.
A number of hydroxychalcones were synthesized to evaluate their protective effects against oxidative cell damage and the production of superoxide anion. The hydroxychalcones which have a 3,4-dihydroxycinnamoyl structure were potent inhibitors of lipid peroxidation in rat liver microsomes. In particular, we found that 2',4',3,4-tetrahydroxychalcone (3) exhibited a potent inhibitory effect on H2O2-induced hemolysis due to an antioxidant effect. In addition, this compound strongly inhibited CCl4-induced cytotoxicity in primary cultured hepatocytes and substantially decreased the production of superoxide anion by rat peritoneal exudate macrophages.
合成了多种羟基查耳酮，以评估它们对细胞氧化损伤的保护作用以及超氧阴离子的产生。具有3,4-二羟基肉桂酰结构的羟基查耳酮是大鼠肝微粒体中脂质过氧化的有效抑制剂。特别地，我们发现2',4',3,4-四羟基查耳酮（3）由于具有抗氧化作用，对H2O2诱导的溶血表现出强大的抑制作用。此外，该化合物强烈抑制原代培养肝细胞中CCl4诱导的细胞毒性，并显著降低大鼠腹腔渗出巨噬细胞中超氧阴离子的产生。
