Xiong Q, Hase K, Tezuka Y, Tani T, Namba T, Kadota S
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.
Planta Med. 1998 Mar;64(2):120-5. doi: 10.1055/s-2006-957387.
Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2'-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl4-induced lipid peroxidation in rat liver microsomes. Addition of them to primary cultured rat hepatocytes efficiently prevented cell damage induced by exposure to CCl4 or D-galactosamine (D-GalN). Acteoside (1) further showed pronounced anti-hepatotoxic activity against CCl4 in vivo.
从肉苁蓉茎中分离出的四种苯乙醇苷，松果菊苷（1）、2'-乙酰松果菊苷（2）、异松果菊苷（3）和管花苷B（4），能显著抑制NADPH/四氯化碳诱导的大鼠肝微粒体脂质过氧化。将它们添加到原代培养的大鼠肝细胞中可有效预防因接触四氯化碳或D-半乳糖胺（D-GalN）而导致的细胞损伤。松果菊苷（1）在体内对四氯化碳还表现出显著的抗肝毒性活性。
