Sandvig K, van Deurs B
Institute for Cancer Research, Norwegian Radium Hospital, Montebello, Oslo.
FEBS Lett. 1994 Jun 6;346(1):99-102. doi: 10.1016/0014-5793(94)00281-9.
Ricin and Shiga toxin belong to a group of protein toxins with targets in the cytosol. These toxins consist of one moiety that binds the toxin molecule to cell surface receptors, and another enzymatically active moiety that enters the cytosol after endocytic uptake of the toxin. The toxins are of current interest in relation to disease and the construction of immunotoxins. Moreover, they have proven useful to investigate mechanisms of endocytosis and to follow intracellular pathways of transport. Some of the recent results obtained with ricin and Shiga toxin are discussed.
蓖麻毒素和志贺毒素属于一类作用于细胞质的蛋白质毒素。这些毒素由一个将毒素分子与细胞表面受体结合的部分和另一个在毒素通过内吞作用进入细胞后进入细胞质的酶活性部分组成。这些毒素在疾病和免疫毒素构建方面具有重要研究价值。此外，它们已被证明有助于研究内吞作用机制以及追踪细胞内运输途径。本文讨论了一些近期关于蓖麻毒素和志贺毒素的研究结果。
