Greco L, Tozzi A E, Mayer M, Grimaldi M, Silano G, Auricchio S
Department of Paediatrics, Second School of Medicine, University of Naples, Italy.
Eur J Pediatr. 1989 Jun;148(7):610-3. doi: 10.1007/BF00441511.
Four hundred and sixty-three new diagnoses of coeliac disease in children were made during 1973 to 1986 in our department. The distribution of new diagnoses per year did not show any decreasing trend in the period 1973 to 1986. No changing trend in breast feeding attitudes was found in the region during the same period. Analysis of the clinical pattern showed a constant distribution of age at diagnosis, onset of first symptoms and nature of symptoms throughout the period studied. These data suggest that coeliac disease is predominantly genetically determined and its expression is modulated by individual and environmental factors. The stability of the observed prevalence of the disease is parallel to the unchanging pattern of breast feeding attitudes in the region.
1973年至1986年期间，我们科室对463名儿童进行了新的乳糜泻诊断。1973年至1986年期间，每年新诊断病例的分布没有显示出任何下降趋势。同期该地区母乳喂养态度没有变化趋势。对临床模式的分析表明，在整个研究期间，诊断时的年龄、首发症状的出现以及症状的性质分布恒定。这些数据表明，乳糜泻主要由基因决定，其表达受个体和环境因素调节。观察到的该疾病患病率的稳定性与该地区母乳喂养态度不变的模式平行。
