CP-62,993、红霉素、克林霉素和四环素对沙眼衣原体的体外评估
In vitro evaluation of CP-62,993, erythromycin, clindamycin, and tetracycline against Chlamydia trachomatis.
作者信息
Walsh M, Kappus E W, Quinn T C
出版信息
Antimicrob Agents Chemother. 1987 May;31(5):811-2. doi: 10.1128/AAC.31.5.811.
Abstract
The antimicrobial activity of CP-62,993 against four Chlamydia trachomatis isolates was compared with those of erythromycin, clindamycin, and tetracycline. The MIC of CP-62,993 was 0.26 to 1.02 micrograms/ml for 100% inclusion inhibition and 0.031 to 0.063 microgram/ml for 50% inclusion inhibition. With pharmacokinetic and antimicrobial studies demonstrating prolonged half-life and in vitro effectiveness, CP-62,993 may make possible a single, short-course treatment regimen for C. trachomatis infection.
摘要
将CP-62,993对四种沙眼衣原体分离株的抗菌活性与红霉素、克林霉素和四环素进行了比较。CP-62,993对100%包涵体抑制的最低抑菌浓度（MIC）为0.26至1.02微克/毫升，对50%包涵体抑制的MIC为0.031至0.063微克/毫升。药代动力学和抗菌研究表明其半衰期延长且体外有效，CP-62,993可能使沙眼衣原体感染的单一短疗程治疗方案成为可能。
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本文引用的文献
1
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Antimicrob Agents Chemother. 1980 Nov;18(5):696-8. doi: 10.1128/AAC.18.5.696.
2
Microtest procedure for isolation of Chlamydia trachomatis.沙眼衣原体分离的微量试验程序。
J Clin Microbiol. 1981 Jun;13(6):1036-9. doi: 10.1128/jcm.13.6.1036-1039.1981.
3
The microbiology and therapy of acute pelvic inflammatory disease in hospitalized patients.
Am J Obstet Gynecol. 1980 Jan 15;136(2):179-86. doi: 10.1016/0002-9378(80)90592-x.
4
Epidemiology of sexually transmitted Chlamydia trachomatis infections.性传播沙眼衣原体感染的流行病学
Epidemiol Rev. 1983;5:96-123. doi: 10.1093/oxfordjournals.epirev.a036266.
5
Detection of Chlamydia trachomatis inclusions in Mccoy cell cultures with fluorescein-conjugated monoclonal antibodies.使用荧光素偶联单克隆抗体检测 McCoy 细胞培养物中的沙眼衣原体包涵体。
J Clin Microbiol. 1983 Apr;17(4):666-8. doi: 10.1128/jcm.17.4.666-668.1983.
6
Treatment of sexually transmitted chlamydial infections.性传播衣原体感染的治疗
JAMA. 1986 Apr 4;255(13):1750-6.
7
Antibiotic susceptibility of Chlamydia trachomatis.沙眼衣原体的抗生素敏感性
Antimicrob Agents Chemother. 1977 Dec;12(6):673-7. doi: 10.1128/AAC.12.6.673.
8
The antimicrobial susceptibility of Chlamydia trachomatis in cell culture.沙眼衣原体在细胞培养中的抗菌药敏性。
Br J Vener Dis. 1978 Apr;54(2):103-6. doi: 10.1136/sti.54.2.103.
9
Chlamydial infections (third of three parts).衣原体感染（三部分之第三部分）
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