Bonnett D E
Department of Medical Physics, Leicester Royal Infirmary, UK.
Phys Med Biol. 1993 Oct;38(10):1371-92. doi: 10.1088/0031-9155/38/10/001.
The use of high-energy protons in radiotherapy was first proposed in 1946. In the last decade there has been a significant growth in the number of centres using protons in the treatment of malignant and non-malignant disease. To date (January 1993) a total of more than 11,500 patients have been treated world-wide. Encouraging clinical results have been reported in the literature. The purpose of this article is to outline the advantages of proton beams and to review current developments in physics and engineering applied to the field of proton therapy with particular emphasis on proton accelerator technology and the development of proton therapy facilities. The production of clinically useful beams is discussed and the relative merits of different treatment systems compared. Reference is also made to the factors affecting the absorbed dose in a patient and to proton radiobiology together with the results of studies of comparisons of treatment planning with protons with that using conventional photon therapy. The dosimetry of proton beams is also reviewed.
1946年首次有人提出在放射治疗中使用高能质子。在过去十年中，使用质子治疗恶性和非恶性疾病的中心数量显著增加。截至1993年1月，全球共有超过11,500名患者接受了治疗。文献中报道了令人鼓舞的临床结果。本文的目的是概述质子束的优势，并回顾应用于质子治疗领域的物理和工程学的当前发展，特别强调质子加速器技术和质子治疗设施的发展。讨论了临床可用束流的产生，并比较了不同治疗系统的相对优点。还提到了影响患者吸收剂量的因素以及质子放射生物学，以及质子治疗计划与传统光子治疗计划比较研究的结果。同时也对质子束的剂量学进行了回顾。
