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Blocking cartilage destruction with metalloproteinase inhibitors: a valid therapeutic target?用金属蛋白酶抑制剂阻断软骨破坏：一个有效的治疗靶点？
Ann Rheum Dis. 1993 Nov;52(11):769-70. doi: 10.1136/ard.52.11.769.
2
Metalloproteinase inhibitors--crystal gazing for a future therapy?金属蛋白酶抑制剂——对未来疗法的空想？
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A synthetic peptide metalloproteinase inhibitor, but not TIMP, prevents the breakdown of proteoglycan within articular cartilage in vitro.一种合成肽金属蛋白酶抑制剂而非组织金属蛋白酶抑制剂，可在体外防止关节软骨内蛋白聚糖的分解。
Agents Actions. 1992 Sep;37(1-2):147-54. doi: 10.1007/BF01987904.
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Metalloproteinases: their role in arthritis and potential as therapeutic targets.金属蛋白酶：它们在关节炎中的作用及作为治疗靶点的潜力。
Expert Opin Ther Targets. 2003 Feb;7(1):19-34. doi: 10.1517/14728222.7.1.19.
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Tissue inhibitors of matrix metalloendopeptidases.基质金属内肽酶组织抑制剂
Methods Enzymol. 1995;248:496-510. doi: 10.1016/0076-6879(95)48032-3.
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Significance of serine proteinase and matrix metalloproteinase systems in the destruction of human articular cartilage.丝氨酸蛋白酶和基质金属蛋白酶系统在人类关节软骨破坏中的意义。
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Clin Chim Acta. 1996 Jan 15;244(1):17-33. doi: 10.1016/0009-8981(95)06172-x.
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Inhibition of interleukin-1alpha-induced cartilage oligomeric matrix protein degradation in bovine articular cartilage by matrix metalloproteinase inhibitors: potential role for matrix metalloproteinases in the generation of cartilage oligomeric matrix protein fragments in arthritic synovial fluid.基质金属蛋白酶抑制剂对白细胞介素-1α诱导的牛关节软骨中软骨寡聚基质蛋白降解的抑制作用：基质金属蛋白酶在关节炎滑液中软骨寡聚基质蛋白片段生成中的潜在作用。
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Suppression of matrix metalloproteinase-3 synthesis by interleukin-4 in human articular chondrocytes.白细胞介素-4对人关节软骨细胞基质金属蛋白酶-3合成的抑制作用。
J Rheumatol. 1997 Sep;24(9):1774-9.

引用本文的文献

1
Inhibitors of collagenase but not of gelatinase reduce cartilage explant proteoglycan breakdown despite only low levels of matrix metalloproteinase activity.胶原酶抑制剂而非明胶酶抑制剂可减少软骨外植体蛋白聚糖的分解，尽管基质金属蛋白酶活性水平较低。
Clin Mol Pathol. 1996 Dec;49(6):M331-9. doi: 10.1136/mp.49.6.m331.
2
Proteolytic mechanisms of cartilage breakdown: a target for arthritis therapy?软骨破坏的蛋白水解机制：关节炎治疗的靶点？
Clin Mol Pathol. 1995 Aug;48(4):M167-77. doi: 10.1136/mp.48.4.m167.
3
Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.在人类关节炎中，聚集蛋白聚糖被基质金属蛋白酶降解。有证据表明基质金属蛋白酶和聚集蛋白聚糖酶的活性可能是独立的。
J Clin Invest. 1996 Nov 15;98(10):2292-9. doi: 10.1172/JCI119040.
4
Inhibition of relaxin-induced pubic symphyseal "relaxation" in guinea pigs by glycosaminoglycan polysulfates and pentosan polysulfate.糖胺聚糖多硫酸盐和戊聚糖多硫酸盐对豚鼠中松弛素诱导的耻骨联合“松弛”的抑制作用。
Agents Actions. 1994 Aug;42(1-2):74-80. doi: 10.1007/BF02014304.

本文引用的文献

1
The measurement of collagenase, tissue inhibitor of metalloproteinases (TIMP), and collagenase-TIMP complex in synovial fluids from patients with osteoarthritis and rheumatoid arthritis.骨关节炎和类风湿关节炎患者滑液中胶原酶、金属蛋白酶组织抑制剂（TIMP）及胶原酶-TIMP复合物的测定。
Arthritis Rheum. 1993 Mar;36(3):372-9. doi: 10.1002/art.1780360313.
2
Crystallization and preliminary X-ray analysis of a truncated tissue metalloproteinase inhibitor delta 128-194 TIMP-2.截短型组织金属蛋白酶抑制剂δ128 - 194（TIMP - 2）的结晶及初步X射线分析
J Mol Biol. 1993 Feb 20;229(4):1163-4. doi: 10.1006/jmbi.1993.1114.
3
Metalloproteinase inhibitors as therapeutics.金属蛋白酶抑制剂作为治疗药物。
Clin Exp Rheumatol. 1993 Mar-Apr;11 Suppl 8:S91-4.
4
Metalloproteinases from rabbit bone culture medium degrade types IV and V collagens, laminin and fibronectin.来自兔骨培养基的金属蛋白酶可降解IV型和V型胶原蛋白、层粘连蛋白和纤连蛋白。
Biochem J. 1981 Dec 1;199(3):807-11. doi: 10.1042/bj1990807.
5
Metalloproteinases and collagenase inhibitors in rheumatoid synovial fluid.类风湿性滑液中的金属蛋白酶和胶原酶抑制剂
Arthritis Rheum. 1984 Mar;27(3):285-90. doi: 10.1002/art.1780270306.
6
The interaction of purified rabbit bone collagenase with purified rabbit bone metalloproteinase inhibitor.纯化的兔骨胶原酶与纯化的兔骨金属蛋白酶抑制剂之间的相互作用。
Biochem J. 1983 May 1;211(2):313-8. doi: 10.1042/bj2110313.
7
The role of proteases in matrix breakdown during cellular invasion.蛋白酶在细胞侵袭过程中基质降解中的作用。
Am Rev Respir Dis. 1989 Oct;140(4):1112-3. doi: 10.1164/ajrccm/140.4.1112.
8
Crystallization and preliminary X-ray analysis of porcine synovial collagenase.猪滑膜胶原酶的结晶及初步X射线分析
J Mol Biol. 1989 Nov 5;210(1):237-8. doi: 10.1016/0022-2836(89)90304-5.
9
Rheumatoid arthritis--its present and future.类风湿关节炎——现状与未来。
J Rheumatol. 1990 Feb;17(2):127-33.
10
In vivo studies of cartilage regeneration after damage induced by catabolin/interleukin-1.关于分解代谢素/白细胞介素-1诱导损伤后软骨再生的体内研究。
Ann Rheum Dis. 1991 Feb;50(2):75-80. doi: 10.1136/ard.50.2.75.

Blocking cartilage destruction with metalloproteinase inhibitors: a valid therapeutic target?

作者信息

Cawston T

机构信息

Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, United Kingdom.

出版信息

Ann Rheum Dis. 1993 Nov;52(11):769-70. doi: 10.1136/ard.52.11.769.

DOI:10.1136/ard.52.11.769
PMID:8250606
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1005185/
Abstract
摘要