正常受试者和支气管扩张症患者纤毛摆动频率的变异性。
Variability in ciliary beat frequency in normal subjects and in patients with bronchiectasis.
作者信息
Veale D, Rodgers A D, Griffiths C J, Ashcroft T, Gibson G J
机构信息
Department of Respiratory Medicine, Freeman Hospital, Newcastle upon Tyne, UK.
出版信息
Thorax. 1993 Oct;48(10):1018-20. doi: 10.1136/thx.48.10.1018.
BACKGROUND
There is a wide variation in tracheobronchial clearance of inhaled aerosol in normal subjects and in patients with bronchiectasis, but little information is available on the variability in ciliary beat frequency (CBF).
METHODS
The variability in CBF was measured in 10 nasal mucosal samples from each of 19 normal controls and 23 stable bronchiectatic subjects.
RESULTS
The CBF varied at different mucosal sites in both normal subjects and bronchiectatic patients. Although the CBF of the fastest beating cilia was similar in both groups, the CBF of the slowest beating cilia was, on average, lower and showed greater within subject variation in bronchiectatic than in normal subjects.
CONCLUSIONS
There is a wide variation in CBF in nasal mucosal samples and this is significantly wider in bronchiectatic subjects with some cilia beating slowly. This may be a consequence of chronic inflammation or infection.
背景
正常受试者和支气管扩张症患者吸入气雾剂后的气管支气管清除率存在很大差异，但关于纤毛摆动频率（CBF）变异性的信息却很少。
方法
对19名正常对照者和23名稳定期支气管扩张症患者的10份鼻黏膜样本进行CBF变异性测量。
结果
正常受试者和支气管扩张症患者的CBF在不同黏膜部位均有变化。虽然两组中摆动最快的纤毛的CBF相似，但支气管扩张症患者中摆动最慢的纤毛的CBF平均较低，且受试者内部变异比正常受试者更大。
结论
鼻黏膜样本中的CBF存在很大差异，在一些纤毛摆动缓慢的支气管扩张症患者中差异更为显著。这可能是慢性炎症或感染的结果。
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