Freire-Maia L, de Matos I M
Departamento de Farmacologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Toxicon. 1993 Sep;31(9):1207-10. doi: 10.1016/0041-0101(93)90137-8.
Experiments were performed in pentobarbital-anesthetized rats, to study the mechanism of the acute pulmonary edema induced by Tityus serrulatus scorpion venom. In control rats injection of venom (50 micrograms/100 g, i.v.) induced arterial hypertension and lung edema (lung/body index or LBI equal to 1.01 +/- 0.09). In rats pretreated with heparin (100 IU/100 g 30 min previously) the venom induced similar hypertensive effects, but no edema was detected (LBI = 0.63 +/- 0.06, P > 0.05). Similarly, in rats pretreated with the PAF antagonist BN-52021 (0.5 mg/100 g, i.v., 30 min previously), the venom-induced hypertension was not modified but the acute pulmonary edema was prevented (LBI = 0.67 +/- 0.08, P > 0.05). It is concluded that PAF plays an important role on the genesis of pulmonary edema induced by scorpion venom in the rat. It is suggested that the inhibitory action of heparin could be related to a decrease in the vascular permeability in the lungs.
实验在戊巴比妥麻醉的大鼠身上进行，以研究巴西金幽灵蝎毒液诱导急性肺水肿的机制。在对照大鼠中，静脉注射毒液（50微克/100克）可导致动脉高血压和肺水肿（肺/体重指数或LBI等于1.01±0.09）。在预先用肝素（100国际单位/100克，30分钟前）处理的大鼠中，毒液诱导了类似的高血压作用，但未检测到水肿（LBI = 0.63±0.06，P>0.05）。同样，在预先用PAF拮抗剂BN-52021（0.5毫克/100克，静脉注射，30分钟前）处理的大鼠中，毒液诱导的高血压未改变，但急性肺水肿得到预防（LBI = 0.67±0.08，P>0.05）。结论是PAF在大鼠蝎毒诱导的肺水肿发生中起重要作用。提示肝素的抑制作用可能与肺血管通透性降低有关。
