Puerta L, Fernández-Caldas E, Lockey R F, Caraballo L R
Laboratory of Immunology, University of Cartagena, Colombia.
J Investig Allergol Clin Immunol. 1993 Jul-Aug;3(4):198-204.
Sensitization to the domestic mites Blomia tropicalis, Chortoglyphus arcuatus, Lepidoglyphus destructor and Aleuroglyphus ovatus was investigated in 77 subjects with clinical symptoms of asthma and/or allergic rhinitis and a positive skin prick test (wheal > or = 3 mm) to Dermatophagoides pteronyssinus and/or D. farinae. Seventy patients were skin test-positive to D. pteronyssinus and 73 to D. farinae. Serum samples from 29 nonallergic, skin test-negative individuals were used as negative controls. Specific IgE was determined by RAST and the results expressed as the % of the total counts bound (% TCB). A positive result (> or = 1% TCB) to D. farinae was detected in 89.6% of subjects, to B. tropicalis in 80.5%, to D. pteronyssinus in 75.3%, to C. arcuatus in 71.4%, to A. ovatus in 68.8% and to L. destructor in 59.7%. None of the controls had a positive RAST to any of the mite species. Different IgE binding patterns were observed among these subjects, suggesting sensitization to unique as well as common allergens in the different mite species. Sensitization to Pyroglyphidae (D. pteronyssinus and D. farinae) and non-Pyroglyphidae mites (B. tropicalis, C. arcuatus, L. destructor and A. ovatus) is common among allergic individuals in Cartagena. Extracts of these mites may be needed for a more accurate diagnosis and effective treatment of respiratory diseases due to mite allergy in tropical environments.
在77名有哮喘和/或变应性鼻炎临床症状且对尘螨和/或粉尘螨皮肤点刺试验呈阳性（风团≥3毫米）的受试者中，研究了对热带无爪螨、弓毛食甜螨、害嗜鳞螨和椭圆食粉螨的致敏情况。70名患者对尘螨皮肤试验呈阳性，73名对粉尘螨呈阳性。来自29名非过敏性、皮肤试验阴性个体的血清样本用作阴性对照。通过放射性变应原吸附试验（RAST）测定特异性IgE，结果以结合的总计数百分比（%TCB）表示。在89.6%的受试者中检测到对粉尘螨的阳性结果（≥1%TCB），对热带无爪螨为80.5%，对尘螨为75.3%，对弓毛食甜螨为71.4%，对椭圆食粉螨为68.8%，对害嗜鳞螨为59.7%。没有一名对照者对任何螨种的RAST呈阳性。在这些受试者中观察到不同的IgE结合模式，表明对不同螨种中的独特过敏原以及常见过敏原均有致敏。在卡塔赫纳的过敏个体中，对尘螨科（尘螨和粉尘螨）和非尘螨科螨（热带无爪螨、弓毛食甜螨、害嗜鳞螨和椭圆食粉螨）的致敏很常见。对于热带环境中因螨过敏引起的呼吸道疾病，可能需要这些螨的提取物来进行更准确的诊断和有效治疗。
