用鼠李糖乳杆菌对早产儿进行肠内喂养。
Enteral feeding of premature infants with Lactobacillus GG.
作者信息
Millar M R, Bacon C, Smith S L, Walker V, Hall M A
机构信息
Department of Microbiology, Royal Hampshire County Hospital, Winchester.
出版信息
Arch Dis Child. 1993 Nov;69(5 Spec No):483-7. doi: 10.1136/adc.69.5_spec_no.483.
The objectives of this study were to determine whether or not the probiotic Lactobacillus GG can colonise the immature bowel of premature infants and if so, does colonisation result in a reduction of the size of the bowel reservoir of nosocomial pathogens such as enterobacteriaceae, enterococci, yeasts or staphylococci, and does colonisation with Lactobacillus GG have any effect on the clinical progress and outcome. Twenty preterm infants with a gestational age of 33 weeks or less who were resident on a neonatal unit were studied from the initiation of milk feeds until discharge. The infants were randomised to receive either milk feeds or milk feeds supplemented with Lactobacillus GG 10(8) colony forming units twice a day for two weeks. The clinical features of the two groups of infants were similar. Orally administered Lactobacillus GG was well tolerated and did colonise the bowel of premature infants. However, colonisation with Lactobacillus GG did not reduce the faecal reservoir of potential pathogens and there was no evidence that colonisation had any positive clinical benefit for this particular group of infants.
本研究的目的是确定益生菌鼠李糖乳杆菌GG是否能定殖于早产儿未成熟的肠道中；如果可以，定殖是否会使肠道中诸如肠杆菌科细菌、肠球菌、酵母菌或葡萄球菌等医院病原体的菌库规模减小，以及鼠李糖乳杆菌GG定殖是否会对临床进展和结局产生任何影响。对20名孕周为33周或更小、住在新生儿病房的早产儿进行研究，从开始喂奶直至出院。将这些婴儿随机分为两组，一组接受单纯喂奶，另一组接受添加了10⁸菌落形成单位鼠李糖乳杆菌GG的喂奶，每天两次，持续两周。两组婴儿的临床特征相似。口服的鼠李糖乳杆菌GG耐受性良好，且确实定殖于早产儿的肠道中。然而，鼠李糖乳杆菌GG定殖并未减少潜在病原体在粪便中的菌库，且没有证据表明定殖对这一特定组的婴儿有任何积极的临床益处。
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