自身免疫易感性小鼠品系中的IgG糖基化
IgG glycosylation in autoimmune-prone strains of mice.
作者信息
Bodman K B, Hutchings P R, Jeddi P A, Delves P J, Rook G A, Sumar N, Roitt I M, Lydyard P M
机构信息
Department of Immunology, University College London Medical School, UK.
出版信息
Clin Exp Immunol. 1994 Jan;95(1):103-7. doi: 10.1111/j.1365-2249.1994.tb06022.x.
The relationship between increased levels of IgG oligosaccharide chains lacking galactose (G0) and the development of rheumatoid arthritis is unclear. In order to further our understanding of the observed correlation between raised serum G0 and arthritis, we have studied G0 levels in arthritis-prone and non-susceptible (i.e. non-arthritis-prone) mice and the effects on G0 of mycobacterial antigens, which have been postulated to play a role in the early events leading to the development of arthritis. We have shown that different age-matched mouse strains have characteristic 'resting' levels of G0 which (in six out of seven strains of mice) increase with age. We have also shown that these increases can be enhanced by immunization of arthritis-prone strains of mice with an adjuvant containing mycobacteria (Freund's complete adjuvant (FCA)), suggesting that deflects in the ability to regulate these G0 changes may be related to susceptibility to arthritis.
缺乏半乳糖的IgG寡糖链（G0）水平升高与类风湿性关节炎的发展之间的关系尚不清楚。为了进一步了解观察到的血清G0升高与关节炎之间的相关性，我们研究了易患关节炎和不易患关节炎（即非易患关节炎）小鼠的G0水平，以及分枝杆菌抗原对G0的影响，据推测分枝杆菌抗原在导致关节炎发展的早期事件中起作用。我们发现，不同年龄匹配的小鼠品系具有特征性的G0“静息”水平，（在七分之六的小鼠品系中）该水平随年龄增长而升高。我们还表明，用含分枝杆菌的佐剂（弗氏完全佐剂（FCA））免疫易患关节炎的小鼠品系可增强这些升高，这表明调节这些G0变化的能力缺陷可能与关节炎易感性有关。
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