铁、荚膜和毒素在创伤弧菌生物2型对小鼠致病性中的作用。
Role of iron, capsule, and toxins in the pathogenicity of Vibrio vulnificus biotype 2 for mice.
作者信息
Amaro C, Biosca E G, Fouz B, Toranzo A E, Garay E
机构信息
Departamento de Microbiología, Facultad de Biología, Universidad de Valencia, Spain.
出版信息
Infect Immun. 1994 Feb;62(2):759-63. doi: 10.1128/iai.62.2.759-763.1994.
Abstract
The virulence mechanisms of Vibrio vulnificus biotype 2 have been studied and compared with those of biotype 1 in mice as the experimental animals. Biotype 2 isolates from European eels were as virulent for mice as biotype 1 strains (50% lethal dose, about 10(5) CFU per mouse); a septicemic infection developed in less than 24 h. These strains had several properties in common with biotype 1 organisms including capsule expression, uptake of various iron sources, and production of exoproteins, whose role in mouse virulence has been demonstrated. We also discuss the implication of biotype 2 strains in human infections.
摘要
已经对创伤弧菌生物型2的毒力机制进行了研究，并在小鼠作为实验动物的情况下与生物型1的毒力机制进行了比较。从欧洲鳗鱼分离出的生物型2菌株对小鼠的毒力与生物型1菌株相同（半数致死剂量，约每只小鼠10(5) CFU）；在不到24小时内就会发展为败血症感染。这些菌株与生物型1菌株有几个共同特性，包括荚膜表达、摄取各种铁源以及产生外蛋白，其在小鼠毒力中的作用已得到证实。我们还讨论了生物型2菌株在人类感染中的意义。
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