Alder J, Mitten M, Jarvis K, Gupta P, Clement J
Anti-Infective Research Division, Abbott Laboratories, Abbott Park, Illinois 60064-3500.
Antimicrob Agents Chemother. 1993 Jun;37(6):1329-33. doi: 10.1128/AAC.37.6.1329.
Clarithromycin provided effective therapy against arthritis induced by Borrelia burgdorferi infection in the hamster. In vitro, clarithromycin was at least 1 log more potent than tetracycline against two isolates of B. burgdorferi from human sources, as measured by MICs and 50% inhibitory concentrations. Clarithromycin was effective in preventing the onset of B. burgdorferi-induced arthritis, as determined by several parameters of paw swelling. When administered after the onset of arthritis, clarithromycin therapy reduced the degree of swelling and decreased recovery time. These results suggest that clarithromycin has potential as an effective therapy for Lyme disease.
克拉霉素对仓鼠因伯氏疏螺旋体感染诱发的关节炎提供了有效的治疗。在体外，通过最小抑菌浓度（MICs）和50%抑制浓度测定，克拉霉素对两株来自人类的伯氏疏螺旋体分离株的效力比四环素至少高1个对数级。通过爪肿胀的几个参数确定，克拉霉素在预防伯氏疏螺旋体诱发的关节炎发作方面有效。当在关节炎发作后给药时，克拉霉素治疗降低了肿胀程度并缩短了恢复时间。这些结果表明克拉霉素有作为莱姆病有效治疗方法的潜力。
