由白色念珠菌特异性T细胞系介导的对小鼠播散性念珠菌病的保护作用。
Protection against murine disseminated candidiasis mediated by a Candida albicans-specific T-cell line.
作者信息
Sieck T G, Moors M A, Buckley H R, Blank K J
机构信息
Department of Pathology and Laboratory Medicine, Hahnemann University School of Medicine, Philadelphia, Pennsylvania 19102.
出版信息
Infect Immun. 1993 Aug;61(8):3540-3. doi: 10.1128/iai.61.8.3540-3543.1993.
Abstract
The role of T lymphocytes in disseminated candidiasis in a mouse model of irradiation-induced immunosuppression was investigated. A continuously cultured Candida albicans-specific T-cell line mediated protection of sublethally irradiated mice from disseminated candidiasis as measured by both the fungal load in the kidneys and mortality. These results are the first to demonstrate directly a role for antigen-specific T cells in the protective immune response against murine disseminated candidiasis.
摘要
研究了T淋巴细胞在辐射诱导免疫抑制小鼠模型的播散性念珠菌病中的作用。通过肾脏中的真菌负荷和死亡率测量，一种连续培养的白色念珠菌特异性T细胞系介导亚致死剂量照射小鼠免受播散性念珠菌病的侵害。这些结果首次直接证明了抗原特异性T细胞在针对小鼠播散性念珠菌病的保护性免疫反应中的作用。
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本文引用的文献
1
Radiosensitive and radioresistant phases in the antibody response.抗体应答中的放射敏感和放射抗性阶段。
J Immunol. 1952 Jun;68(6):693-700.
2
Fungal infection in chronic granulomatous disease. The importance of the phagocyte in defense against fungi.慢性肉芽肿病中的真菌感染。吞噬细胞在抗真菌防御中的重要性。
Am J Med. 1981 Jul;71(1):59-66. doi: 10.1016/0002-9343(81)90259-x.
3
4
Identification and molecular weight characterization of antigens from Candida albicans that are recognized by human sera.白色念珠菌中可被人血清识别的抗原的鉴定及分子量表征
Infect Immun. 1984 Feb;43(2):715-21. doi: 10.1128/iai.43.2.715-721.1984.
5
Candidiasis in cancer patients.癌症患者的念珠菌病。
Am J Med. 1984 Oct 30;77(4D):13-9.
6
Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection.白细胞髓过氧化物酶缺乏与播散性念珠菌病：髓过氧化物酶在抵抗念珠菌感染中的作用
J Clin Invest. 1969 Aug;48(8):1478-88. doi: 10.1172/JCI106114.
7
Immune abnormalities associated with chronic mucocutaneous candidiasis.与慢性黏膜皮肤念珠菌病相关的免疫异常。
Cell Immunol. 1973 Mar;6(3):348-61. doi: 10.1016/0008-8749(73)90035-x.
8
Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.干扰素-γ和肿瘤坏死因子对人多形核中性粒细胞功能的激活作用。
J Immunol. 1985 Sep;135(3):2069-73.
9
Fungal infections in patients with AIDS and AIDS-related complex.艾滋病及艾滋病相关综合征患者的真菌感染
Scand J Infect Dis. 1986;18(3):179-92. doi: 10.3109/00365548609032326.
10
Inoculation candidiasis in a murine model of severe combined immunodeficiency syndrome.重度联合免疫缺陷综合征小鼠模型中的接种念珠菌病
Infect Immun. 1988 Dec;56(12):3162-6. doi: 10.1128/iai.56.12.3162-3166.1988.
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