Maurin M, Lepocher H, Mallet D, Raoult D
Unite des Rickettsies, Faculte de Medecine, Marseille, France.
Antimicrob Agents Chemother. 1993 Jul;37(7):1410-3. doi: 10.1128/AAC.37.7.1410.
Afipia felis, one of the putative agents of cat scratch disease (CSD), is a facultative intracellular bacterium. Although CSD is considered not to be susceptible to antibiotic therapy, sporadic case reports indicated that aminoglycosides may be effective. We determined the in vitro antibiotic susceptibilities of three A. felis strains in axenic medium and in a cell model. In axenic medium, A. felis was susceptible to imipenem, aminoglycosides, and rifampin when using either the broth dilution technique or the agar technique. When grown in HeLa cells, A. felis was susceptible to amikacin and tobramycin but was resistant to the other compounds tested. Despite its intracellular location, A. felis can apparently be reached by aminoglycosides. Thus, the in vitro data presented here are in accord with the clinical data obtained in patients suffering CSD.
猫阿菲彼亚菌是猫抓病（CSD）的假定病原体之一，是一种兼性胞内细菌。尽管猫抓病被认为对抗生素治疗不敏感，但零星的病例报告表明氨基糖苷类药物可能有效。我们在无菌培养基和细胞模型中测定了三株猫阿菲彼亚菌的体外抗生素敏感性。在无菌培养基中，使用肉汤稀释技术或琼脂技术时，猫阿菲彼亚菌对亚胺培南、氨基糖苷类药物和利福平敏感。当在HeLa细胞中生长时，猫阿菲彼亚菌对阿米卡星和妥布霉素敏感，但对其他测试化合物耐药。尽管猫阿菲彼亚菌位于细胞内，但氨基糖苷类药物显然可以作用于它。因此，此处给出的体外数据与猫抓病患者的临床数据一致。
