Middleton P J, Larke R P, Lessard P, Doran T A
Can Med Assoc J. 1977 Mar 5;116(5):484-8.
Despite the availability of rubella vaccine the incidence of the congenital rubella syndrome has been increasing in certain regions of Canada. Perhaps this is not surprising in view of the known irregular cyclic activity of rubella virus in a community and the fact that the percentage of seropositive women of childbearing age has not changed appreciable since the vaccine was introduced. Clearly vaccine is not being administered to sufficient numbers of women at risk. Until a much higher percentage of women of childbearing age possess rubella antibody, the costly problem of congenital rubella syndrome is likely to be with us. Common rubella problems relate to four categories: the exposed pregnant woman, laboratory diagnosis, the infant with suspected congenital rubella and the vaccine. One of the most common questions about the vaccine is the following: Can recently vaccinated individuals disseminate vaccine and infect seronegative contact? The answer is No.
尽管有风疹疫苗,但加拿大某些地区先天性风疹综合征的发病率一直在上升。鉴于风疹病毒在社区中已知的不规则周期性活动,以及自引入疫苗以来育龄血清阳性女性的比例没有明显变化,这或许并不令人惊讶。显然,没有给足够数量的高危女性接种疫苗。在育龄女性中拥有风疹抗体的比例大幅提高之前,先天性风疹综合征这个代价高昂的问题可能会一直存在。常见的风疹问题涉及四类:暴露的孕妇、实验室诊断、疑似先天性风疹的婴儿以及疫苗。关于疫苗最常见的问题之一如下:近期接种疫苗的个体能否传播疫苗并感染血清阴性的接触者?答案是否定的。