Gupta M A, Schork N J, Gupta A K, Kirkby S, Ellis C N
Department of Psychiatry, University of Michigan Medical School, Ann Arbor.
Int J Dermatol. 1993 Mar;32(3):188-90. doi: 10.1111/j.1365-4362.1993.tb02790.x.
Psoriasis has been associated with depressive disease and case reports of completed suicide.
217 consenting psoriasis patients completed the Carroll Rating Scale for Depression (CRSD), a 52-item self-rated scale, with four of the items directly addressing wishes to be dead and suicidal ideation. The patients also self-rated the severity of their psoriasis.
9.7% of patients reported a wish to be dead, and 5.5% reported active suicidal ideation at the time of the study. The death wish and suicidal ideation were associated with higher depression scores (P < 0.0001) and higher patient self-ratings of psoriasis severity (P < 0.05). Patient self-reports of psoriasis severity correlated directly with the overall depression scores (r = 0.39), P < 0.0001).
The comorbidity between depressive symptoms, suicidal ideation, and psoriasis severity is in contrast with reports that severe depression and suicidal ideation are mainly a feature of life-threatening medical disorders such as malignancies. Our finding may have important implications in the management of psoriasis.
银屑病与抑郁症及自杀身亡的病例报告有关。
217名同意参与研究的银屑病患者完成了卡罗尔抑郁评定量表(CRSD),这是一个包含52个项目的自评量表,其中有4个项目直接涉及想死的愿望和自杀意念。患者还对自己银屑病的严重程度进行了自评。
9.7%的患者报告有想死的愿望,5.5%的患者在研究时报告有积极的自杀意念。想死的愿望和自杀意念与更高的抑郁评分(P < 0.0001)以及患者对银屑病严重程度的更高自评分数(P < 0.05)相关。患者对银屑病严重程度的自我报告与总体抑郁评分直接相关(r = 0.39,P < 0.0001)。
抑郁症状、自杀意念和银屑病严重程度之间的共病情况与以下报告形成对比,即严重抑郁和自杀意念主要是诸如恶性肿瘤等危及生命的疾病的特征。我们的发现可能对银屑病的治疗具有重要意义。