Manni R, Ratti M T, Galimberti C A, Morini R, Perucca E, Tartara A
Institute of Neurology CN Mondino, Epilepsy Centre via Palestro, Pavia, Italy.
Neurophysiol Clin. 1993 Jan;23(1):71-6. doi: 10.1016/s0987-7053(05)80284-9.
A multiparametric investigation of daytime sleepiness was carried out in 10 patients with a generalized epilepsy treated by phenobarbital, 10 with a cryptogenic partial epilepsy treated by carbamazepine and 10 healthy controls. After a standard ambulatory night-time polysomnography, an objective and subjective estimate of daytime sleepiness was made in each subject by means of the Multiple Sleep Latency Test (MSLT) and visual analogue rating scale (VARS), respectively. Furthermore, a parallel assessment of mood and cognitive tasks involving attention and psychomotor speed was also carried out. The data show that patients on chronic treatment with phenobarbital have a greater daytime sleep tendency and they show a worse score at the digit symbol substitution test, than patients on carbamazepine and healthy controls.
对10例接受苯巴比妥治疗的全身性癫痫患者、10例接受卡马西平治疗的隐源性部分性癫痫患者和10名健康对照者进行了白天嗜睡的多参数调查。在进行标准的动态夜间多导睡眠图检查后，分别通过多次睡眠潜伏期试验（MSLT）和视觉模拟评分量表（VARS）对每个受试者白天嗜睡情况进行客观和主观评估。此外，还对情绪以及涉及注意力和精神运动速度的认知任务进行了平行评估。数据显示，与接受卡马西平治疗的患者和健康对照者相比，长期接受苯巴比妥治疗的患者白天睡眠倾向更大，并且在数字符号替换测试中的得分更低。
