Salzman M B, Isenberg H D, Rubin L G
Department of Pediatrics, Schneider Children's Hospital of Long Island Jewish Medical Center, New Hyde Park, New York 11042.
J Clin Microbiol. 1993 Mar;31(3):475-9. doi: 10.1128/jcm.31.3.475-479.1993.
The vascular catheter hub is a potential portal of entry for microorganisms that cause catheter-related sepsis. Thus, a reduction in catheter hub contamination might reduce the incidence of catheter-related sepsis. To develop a regimen suitable for reducing microbial contamination of the catheter hub, we experimentally contaminated catheter hubs and assessed the efficacies of disinfectant solutions. Catheter hubs were incubated overnight with suspensions of Staphylococcus epidermidis, Pseudomonas aeruginosa, or Candida parapsilosis. After removal of unattached microorganisms, the catheter hubs were swabbed by rotating cotton swabs dipped in 1% chlorhexidine, 1% chlorhexidine in 70% ethanol, 70% ethanol, 97% ethanol, or normal saline. Posttreatment swabs of the catheter hub were obtained and cultured quantitatively. The cleaning regimens containing ethanol were the most effective. Seventy percent ethanol was more effective than chlorhexidine and is likely to be the safest treatment. We conclude that cleaning of the catheter hub with disinfectant can dramatically reduce microbial contamination.
血管导管接头是导致导管相关败血症的微生物的一个潜在入口。因此，减少导管接头污染可能会降低导管相关败血症的发生率。为了制定一种适合减少导管接头微生物污染的方案，我们对导管接头进行了实验性污染，并评估了消毒剂溶液的效果。将导管接头与表皮葡萄球菌、铜绿假单胞菌或近平滑念珠菌的悬浮液一起孵育过夜。去除未附着的微生物后，用浸有1%氯己定、70%乙醇中的1%氯己定、70%乙醇、97%乙醇或生理盐水的旋转棉拭子擦拭导管接头。获取导管接头的处理后拭子并进行定量培养。含乙醇的清洁方案最有效。70%乙醇比氯己定更有效，并且可能是最安全的处理方法。我们得出结论，用消毒剂清洁导管接头可显著减少微生物污染。
