[利用卤虫生物测定法预测抗菌及药理活性]
[Bioessay with brine Artemia to predict antibacterial and pharmacologic activity].
作者信息
Sánchez C, Gupta M, Vásquez M, de Noriega Y M, Montenegro G
机构信息
Departamento de Farmacología en la Facultad de Medicina, Universidad de Panamá.
出版信息
Rev Med Panama. 1993 Jan;18(1):62-9.
The Brine Shrimp Test (BST) is a simple and inexpensive method to test cytotoxity, to biodirect phytochemical fractionation of natural products and as a predictor for antitumor and pesticidal activity. In this work, the BST test, an antibacterial test and the rat hippocratic screening test were used on 25 plant extracts and fractions, to evaluate the correlation, if any, between the BST and the others. Preliminary results show that the BST is not a predictor of antibacterial activity nor the hippocratic screening test.
卤虫试验（BST）是一种用于测试细胞毒性、对天然产物进行生物导向植物化学分级分离以及预测抗肿瘤和杀虫活性的简单且廉价的方法。在这项研究中，对25种植物提取物和馏分进行了卤虫试验、抗菌试验和大鼠希波克拉底筛选试验，以评估卤虫试验与其他试验之间是否存在相关性。初步结果表明，卤虫试验既不能预测抗菌活性，也不能预测希波克拉底筛选试验结果。
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