Comparative analysis of scrapie agent inactivation methods.

作者信息

Ernst D R, Race R E

机构信息

National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, Hamilton, MT 59840.

出版信息

J Virol Methods. 1993 Feb;41(2):193-201. doi: 10.1016/0166-0934(93)90126-c.

DOI:10.1016/0166-0934(93)90126-c

PMID:8496294

Abstract

A scrapie-infected hamster brain homogenate was subjected to several different potential inactivation methods. Methods included autoclaving for various lengths of time, either alone or in combination with different concentrations of sodium hydroxide or LpH, an aqueous acid phenolic derivative (Calgon Vestal Laboratories in St. Louis, MO). Inactivation treatments utilizing either NaOH or LpH alone were also evaluated. It was determined that several of the treatments inactivated all of the detectable infectivity.

摘要