Zimmermann A, Flores-de-Jacoby L, Pan P, Pan P
Department of Periodontology, School of Dentistry, Philipps University Marburg, FRG.
J Clin Periodontol. 1993 May;20(5):346-51. doi: 10.1111/j.1600-051x.1993.tb00371.x.
The effectiveness of amine fluoride and stannous fluoride in the prophylaxis of caries and gingivitis is well-known from the literature. The aim of this study was to assess whether these agents could be recommended for long-term use. Under conditions of a clinical double-blind study, the influence of an amine/stannous fluoride rinse on gingivitis, plaque accumulation and the composition of the supragingival plaque was tested over a period of 7 months. 102 persons with signs of chronic gingivitis participated in the study. Gingival indices (GI, SBI) and plaque indices (PlI, API) were recorded at baseline, after 3.5 and 7 months. The composition of the supragingival plaque was evaluated by dark-field microscopy. During the 7 months, the GI decreased in the test group from 1.36 to 0.95, and the SBI from 52.0% to 29.3%. The PlI fell from 1.17 to 0.68, and the API from 61.3% to 50.6% (p < 0.001). No significant changes were recorded in the control group. In the test group, the proportion of cocci in the plaque increased from 58.4% to 68.9% (p < 0.001) while the proportion of rods and other plaque bacteria underwent a significant decrease (p < 0.001). The microflora was stable in the control group throughout the study period. No side-effects of the drug were reported by the probands. The results suggest that long-term use of the amine/stannous fluoride rinse is of benefit to gingival health.
文献中已充分表明胺氟化物和氟化亚锡在预防龋齿和牙龈炎方面的有效性。本研究的目的是评估这些制剂是否可推荐长期使用。在临床双盲研究条件下，测试了胺/氟化亚锡漱口水在7个月期间对牙龈炎、牙菌斑积聚和龈上菌斑成分的影响。102名有慢性牙龈炎体征的人参与了该研究。在基线、3.5个月和7个月后记录牙龈指数（GI、SBI）和菌斑指数（PlI、API）。通过暗视野显微镜评估龈上菌斑的成分。在7个月期间，测试组的GI从1.36降至0.95，SBI从52.0%降至29.3%。PlI从1.17降至0.68，API从61.3%降至50.6%（p<0.001）。对照组未记录到显著变化。在测试组中，菌斑中球菌的比例从58.4%增加到68.9%（p<0.001），而杆菌和其他菌斑细菌的比例则显著下降（p<0.001）。在整个研究期间，对照组的微生物群稳定。受试者未报告该药物的副作用。结果表明，长期使用胺/氟化亚锡漱口水对牙龈健康有益。
