Rubio C A
Obstet Gynecol. 1977 May;49(5):576-80.
One hundred and sixty-six conventional instruments of cell sampling used in gynecologic cytology were investigated after collecting tumor cells and normal squamous cells in vitro. Histologic preparations as well as scanning electronmicroscopic observations of wooden spatulas and cotton swab applicators revealed that despite smearing the material onto a slide, a large number of tumor cells remained trapped in the frames of such instruments. Five percent of the smears obtained showed no tumor cells. Similar results were obtained in preliminary observations in gynecologic patients having cervical atypias. The possibility was entertained that wooden spatulas and cotton swabs may be a source of some of the false negative results in gynecologic cytology.
在体外收集肿瘤细胞和正常鳞状细胞后，对166件用于妇科细胞学检查的传统细胞采样器械进行了研究。对木制刮板和棉签涂抹器进行组织学制片以及扫描电子显微镜观察发现，尽管已将材料涂抹在载玻片上，但仍有大量肿瘤细胞被困在这些器械的框架中。所获得的涂片中有5%未显示肿瘤细胞。在对患有宫颈异型增生的妇科患者进行的初步观察中也得到了类似结果。人们认为木制刮板和棉签可能是导致妇科细胞学检查出现一些假阴性结果的原因之一。
