Parodi M B, Visintin F, Della Rupe P, Ravalico G
Eye Clinic, University of Trieste, Italy.
Int Ophthalmol. 1995;19(1):25-8. doi: 10.1007/BF00156415.
The mean area of the foveal avascular zone (FAZ) in normal subjects was reported as 0.231 mm2 to 0.405 mm2, using fluorescein angiography. The FAZ enlarges in vaso-occlusive diseases, especially diabetic retinopathy, sickle cell retinopathy, talc retinopathy and branch retinal vein occlusion. In the present study the FAZ of 20 patients affected by macular branch retinal vein occlusion (MBRVO) was compared with the FAZ of 41 control subjects. The FAZ mean area was 0.56 +/- 0.34 mm2 SD in the MBRVO group, while 0.26 +/- 0.07 mm2 SD in the control group, with a statistically significant difference (p < 0.001). The FAZ mean perimeter was 4.77 +/- 1.90 mm SD in the MBRVO group, and 2.36 +/- 0.32 mm SD in the control group, with a statistically significant difference (p < 0.001). Taking into account the MBRVO group, a statistical correlation was found between visual acuity impairment and FAZ enlargement (p = 0.02), but not between visual acuity impairment and macular edema (p = 0.41). In 14 cases (70%) secondary avascular microzones located in the macular sector correspondent to MBRVO were also evident. MBRVO causes an irregular enlargement of the FAZ which seems to represent the most important feature related to visual acuity impairment.
据报道，使用荧光素血管造影术测得正常受试者的黄斑无血管区（FAZ）平均面积为0.231平方毫米至0.405平方毫米。在血管闭塞性疾病中，尤其是糖尿病性视网膜病变、镰状细胞性视网膜病变、滑石粉性视网膜病变和视网膜分支静脉阻塞，FAZ会扩大。在本研究中，对20例患有黄斑分支视网膜静脉阻塞（MBRVO）的患者的FAZ与41例对照受试者的FAZ进行了比较。MBRVO组的FAZ平均面积为0.56±0.34平方毫米标准差，而对照组为0.26±0.07平方毫米标准差，差异具有统计学意义（p<0.001）。MBRVO组的FAZ平均周长为4.77±1.90毫米标准差，对照组为2.36±0.32毫米标准差，差异具有统计学意义（p<0.001）。在MBRVO组中，发现视力损害与FAZ扩大之间存在统计学相关性（p=0.02），但视力损害与黄斑水肿之间不存在相关性（p=0.41）。在14例（70%）病例中，位于与MBRVO相对应的黄斑区的继发性无血管微区也很明显。MBRVO导致FAZ不规则扩大，这似乎是与视力损害相关的最重要特征。
