Frur介导大肠杆菌中丙酮酸激酶（pykF）基因表达的分解代谢物激活。
Frur mediates catabolite activation of pyruvate kinase (pykF) gene expression in Escherichia coli.
作者信息
Bledig S A, Ramseier T M, Saier M H
机构信息
Department of Biology, University of California at San Diego, La Jolla 92093-0116, USA.
出版信息
J Bacteriol. 1996 Jan;178(1):280-3. doi: 10.1128/jb.178.1.280-283.1996.
Abstract
Expression of a pykF-lacZ fusion was studied as a function of the carbon source in wild-type strains and strains lacking or overproducing the FruR protein of Escherichia coli. FruR controls the response to the carbon source by repressing pykF expression more strongly under gluconeogenic than under glycolytic conditions, a phenomenon we term catabolite activation.
摘要
在野生型菌株以及缺乏或过量表达大肠杆菌FruR蛋白的菌株中，研究了pykF-lacZ融合蛋白的表达与碳源的关系。FruR通过在糖异生条件下比在糖酵解条件下更强烈地抑制pykF表达来控制对碳源的反应，我们将这一现象称为分解代谢物激活。
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