McGlinchey-Berroth R, Cermak L S, Carrillo M C, Armfield S, Gabrieli J D, Disterhoft J F
Memory Disorders Research Center, Boston University School of Medicine, Massachusetts, USA.
Alcohol Clin Exp Res. 1995 Oct;19(5):1127-32. doi: 10.1111/j.1530-0277.1995.tb01590.x.
The performance of amnesic Korsakoff patients in delay eyeblink classical conditioning was compared with that of recovered chronic alcoholic subjects and healthy normal control subjects. Normal control subjects exhibited acquisition of conditioned responses (CRs) to a previously neutral, conditioned tone stimulus (CS) following repeated pairings with an unconditioned air-puff stimulus, and demonstrated extinction of CRs when the CS was subsequently presented alone. Both amnesic Korsakoff patients and recovered chronic alcoholic subjects demonstrated an impairment in their ability to acquire CRs. These results indicate that the preservation of delay eyeblink conditioning in amnesia must depend on the underlying neuropathology of the amnesic syndrome. It is known that patients with amnesia caused by medial temporal lobe pathology have preserved conditioning. We have now demonstrated that patients with amnesia caused by Korsakoff's syndrome, as well as recovered chronic alcoholic subjects, have impaired conditioning. This impairment is most likely caused by cerebellar deterioration resulting from years of alcohol abuse.
将遗忘型柯萨科夫综合征患者在延迟眨眼经典条件反射中的表现与康复的慢性酒精中毒受试者以及健康正常对照受试者进行了比较。正常对照受试者在与无条件吹气刺激反复配对后，对先前中性的条件性音调刺激（CS）表现出条件反应（CRs）的习得，并在随后单独呈现CS时表现出CRs的消退。遗忘型柯萨科夫综合征患者和康复的慢性酒精中毒受试者在获得CRs的能力上均表现出受损。这些结果表明，遗忘症中延迟眨眼条件反射的保留必须依赖于遗忘综合征的潜在神经病理学。众所周知，由内侧颞叶病变引起的遗忘症患者保留了条件反射。我们现在已经证明，由柯萨科夫综合征引起的遗忘症患者以及康复的慢性酒精中毒受试者，其条件反射受损。这种损伤很可能是由多年酗酒导致的小脑退化引起的。
