Compston J E, Creamer B
Gut. 1977 Mar;18(3):171-5. doi: 10.1136/gut.18.3.171.
Plasma levels of 25-hydroxyvitamin D (25-OHD) were found to be significantly reduced in a group of patients with small bowel resection when compared with normal controls. Plasma levels of 25-OHD after an oral dose of 25-hydroxyvitamin D3 (25-ohd3) were also reduced in the patient group. Dietary intake of vitamin D tended to be low in many patients, but seasonal variation of plasma 25-OHD levels indicated normal exposure to sunlight in most of the patients studied. It is suggested that these studies provide some evidence for malabsorption of 25-OHD after small bowel resection, which, it is postulated, may be due to interruption of the enterohepatic circulation of bile acids and of 25-OHD. These factors may contribute towards the low plasma levels of 25-OHD found in the patient group.
与正常对照组相比，一组小肠切除患者的血浆25-羟维生素D（25-OHD）水平显著降低。患者组口服一剂25-羟维生素D3（25-ohd3）后的血浆25-OHD水平也降低。许多患者的维生素D膳食摄入量往往较低，但血浆25-OHD水平的季节性变化表明，大多数研究对象的阳光照射正常。这些研究表明，小肠切除术后25-OHD吸收不良存在一些证据，据推测，这可能是由于胆汁酸和25-OHD的肠肝循环中断所致。这些因素可能导致患者组血浆25-OHD水平较低。
