细胞免疫的介质。十二、新城疫病毒对活化T细胞的抑制作用。
The mediator of cellular immunity. XII. Inhibition of activated T cells by Newcastle disease virus.
作者信息
McGregor D D, Logie P S, Carmichael L E
出版信息
J Exp Med. 1976 Sep 1;144(3):627-43. doi: 10.1084/jem.144.3.627.
Newcastle disease virus (NDV) can interact in at least two ways with rat T cells. By adsorbing to circulating lymphocytes, the virus can transiently deflect the cells from lymph nodes and inflammatory exudates induced in the peritoneal cavity. T cells are affected regardless of age, state of activation, or position in the mitotic cycle. The effect is reversible and is mediated not only by infectious (I)-NDV, but also by UV-NDV which cannot achieve a complete replication cycle in eggs. But I-NDV has another lasting effect on activated T cells. It is revealed in the failure of virus-treated thoracic duct lymphocytes to transfer cellular resistance to Listeria monocytogenes, delayed-type hypersensitivity to soluble antigens of the parasite, and the permanent exclusion of labeled S-phase lymphocytes from inflammatory foci. Activated T cells are inhibited by virus multiplicites which have little if any effect upon the proliferative potential of antigen-sensitive T cells or localization of labeled small lymphocytes in lymph nodes. The underlying mechanism has not been determined; however, there are reasons for thinking that NDV has a lethal effect upon activated T cells, because the latter are permissive for virus replication.
新城疫病毒（NDV）与大鼠T细胞相互作用至少有两种方式。通过吸附循环淋巴细胞，该病毒可使细胞暂时偏离淋巴结和腹腔内诱导产生的炎性渗出物。无论年龄、激活状态或有丝分裂周期中的位置如何，T细胞都会受到影响。这种作用是可逆的，不仅由感染性（I）-NDV介导，还由紫外线照射过的NDV介导，紫外线照射过的NDV在鸡胚中无法完成完整的复制周期。但I-NDV对活化T细胞还有另一种持久影响。这表现在经病毒处理的胸导管淋巴细胞无法传递对单核细胞增生李斯特菌的细胞抵抗力、对该寄生虫可溶性抗原的迟发型超敏反应，以及标记的S期淋巴细胞被永久性排除在炎症灶之外。病毒剂量会抑制活化T细胞，而这些剂量对抗原敏感T细胞的增殖潜能或标记的小淋巴细胞在淋巴结中的定位几乎没有影响。其潜在机制尚未确定；然而，有理由认为NDV对活化T细胞具有致死作用，因为活化T细胞允许病毒复制。
Zotero 插件