Botelho P J, Johnson L N, Arnold A C
Mason Institute of Ophthalmology, University of Missouri-Columbia, Missouri 65212, USA.
Am J Ophthalmol. 1996 Apr;121(4):450-1. doi: 10.1016/s0002-9394(14)70448-9.
To examine the effect of aspirin use on the visual outcome of nonarteritic anterior ischemic optic neuropathy.
This retrospective case-controlled study included 23 patients who used aspirin regularly before and during the course of nonarteritic anterior ischemic optic neuropathy and 55 control patients with nonarteritic anterior ischemic optic neuropathy. Snellen visual acuity in logMAR and mean deviation on automated perimetry were compiled from the initial and final follow-up examinations.
The comparisons of patients who took aspirin with control patients disclosed that neither initial logMAR (P = .36) nor the follow-up logMAR (P = .95) data differed significantly. There was no significant difference between the groups for the initial (P = .60) and the follow-up mean deviation (P = .41).
Aspirin use does not improve the visual outcome of patients with nonarteritic anterior ischemic optic neuropathy. Additional studies are needed to further elucidate this issue.
探讨使用阿司匹林对非动脉炎性前部缺血性视神经病变视觉预后的影响。
这项回顾性病例对照研究纳入了23例在非动脉炎性前部缺血性视神经病变病程之前及期间规律使用阿司匹林的患者，以及55例非动脉炎性前部缺血性视神经病变的对照患者。从初次及最终随访检查中收集logMAR视力和自动视野检查的平均偏差。
服用阿司匹林的患者与对照患者的比较显示，初始logMAR数据（P = 0.36）和随访logMAR数据（P = 0.95）均无显著差异。两组在初始平均偏差（P = 0.60）和随访平均偏差（P = 0.41）方面均无显著差异。
使用阿司匹林并不能改善非动脉炎性前部缺血性视神经病变患者的视觉预后。需要进一步的研究来阐明这一问题。
