Lai Y M, Yang F P, Pao C C
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China.
Fertil Steril. 1996 May;65(5):1026-30.
To investigate the possible presence and expression of human papillomavirus viruses (HPV) in human plasma and sperm cells.
Controlled clinical study.
A major medical center affiliated with a medical college.
Twenty-four randomly selected patients who attended Fertility Clinics at the Chang Gung Memorial Hospital.
Specimens of semen were collected from volunteered patients
The presence of HPV types 16 and 18 DNA and RNA sequences were examined by polymerase chain reaction.
Human papillomavirus type 16 E6 and E7 DNA and RNA sequences were found in two and zero seminal plasma specimens, respectively, and in six and two sperm cells specimens, respectively. Deoxyribonucleic acid and RNA sequences of HPV type 18 were found in eight and two seminal specimens and in 11 and 5 sperm cells specimens, respectively.
These results seem to suggest that HPV cannot only infect human sperm cells, certain HPV genes are expressed actively in infected sperm cells. The virus-infected sperm cells conceivably can behave as vectors or carriers for the transmission of HPV, to sexual partner during sexual contact, to fetuses through fertilized eggs, or both.
研究人乳头瘤病毒（HPV）在人血浆和精子细胞中的可能存在情况及表达情况。
对照临床研究。
一所医学院附属的大型医疗中心。
从长庚纪念医院生育诊所随机选取的24名患者。
从自愿参与的患者中采集精液样本。
通过聚合酶链反应检测16型和18型HPV的DNA和RNA序列的存在情况。
在两份精液样本中分别检测到16型人乳头瘤病毒E6和E7 DNA序列，在零份精液样本中检测到其RNA序列；在六份和两份精子细胞样本中分别检测到其DNA和RNA序列。在八份和两份精液样本中分别检测到18型HPV的DNA和RNA序列，在11份和五份精子细胞样本中分别检测到其DNA和RNA序列。
这些结果似乎表明，HPV不仅能感染人类精子细胞，某些HPV基因在受感染的精子细胞中还会活跃表达。可以想象，受病毒感染的精子细胞可能作为载体，在性接触过程中将HPV传播给性伴侣，或通过受精卵传播给胎儿，或两者皆有。
