Sutka J, Cagán S
IV. interná klinika LF UK, Bratislava.
Vnitr Lek. 1996 Jan;42(1):37-42.
Recently in the world literature with increasing frequency reports are found on clinical studies investigating the use of beta-blockers in the treatment of chronic heart failure. The authors present a review of the problem comprising pathophysiological mechanisms at a receptor level up to investigations of the effect of beta-blockers on haemodynamics, the functional state of the left ventricle and survival. Although this promising and frequently controversial treatment is not accepted universally so far, partial data in the mentioned investigations indicate that when a more accurate dosage pattern is established and indications are specified in more detail, the use of beta-blockers is one way how to approach - in addition to the use of diuretics, cardiotonics and angiotensin converting enzyme inhibitors - a comprehensive therapeutic control of chronic heart failure.
最近，世界文献中越来越频繁地出现关于研究β受体阻滞剂治疗慢性心力衰竭的临床研究报告。作者对该问题进行了综述，内容涵盖从受体水平的病理生理机制到β受体阻滞剂对血流动力学、左心室功能状态和生存率影响的研究。尽管这种有前景且常引发争议的治疗方法目前尚未被普遍接受，但上述研究中的部分数据表明，当建立更精确的给药模式并更详细地明确适应症时，使用β受体阻滞剂是除使用利尿剂、强心剂和血管紧张素转换酶抑制剂之外，实现慢性心力衰竭综合治疗控制的一种方法。
