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本文引用的文献

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Transcriptional and posttranslational regulation of the general amino acid permease of Saccharomyces cerevisiae.酿酒酵母通用氨基酸通透酶的转录和翻译后调控
J Bacteriol. 1995 Jan;177(1):94-102. doi: 10.1128/jb.177.1.94-102.1995.
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Recognition of nitrogen-responsive upstream activation sequences of Saccharomyces cerevisiae by the product of the GLN3 gene.GLN3基因产物对酿酒酵母氮响应上游激活序列的识别。
J Bacteriol. 1995 Jul;177(14):4190-3. doi: 10.1128/jb.177.14.4190-4193.1995.
3
Genetic evidence for Gln3p-independent, nitrogen catabolite repression-sensitive gene expression in Saccharomyces cerevisiae.酿酒酵母中不依赖Gln3p的、对氮代谢物阻遏敏感的基因表达的遗传证据。
J Bacteriol. 1995 Dec;177(23):6910-8. doi: 10.1128/jb.177.23.6910-6918.1995.
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Role of the GATA factors Gln3p and Nil1p of Saccharomyces cerevisiae in the expression of nitrogen-regulated genes.酿酒酵母的GATA因子Gln3p和Nil1p在氮调节基因表达中的作用。
Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9450-4. doi: 10.1073/pnas.92.21.9450.
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Transformation of intact yeast cells treated with alkali cations.经碱金属阳离子处理的完整酵母细胞的转化
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Mutational analysis of upstream activation sequence 2 of the CYC1 gene of Saccharomyces cerevisiae: a HAP2-HAP3-responsive site.酿酒酵母CYC1基因上游激活序列2的突变分析：一个HAP2 - HAP3反应位点。
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Multiple factors bind the upstream activation sites of the yeast enolase genes ENO1 and ENO2: ABFI protein, like repressor activator protein RAP1, binds cis-acting sequences which modulate repression or activation of transcription.多种因素与酵母烯醇化酶基因ENO1和ENO2的上游激活位点结合：ABFI蛋白与阻遏激活蛋白RAP1一样，能结合顺式作用序列，这些序列可调节转录的抑制或激活。
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Recovery of plasmids from yeast into Escherichia coli: shuttle vectors.从酵母中回收质粒并导入大肠杆菌：穿梭载体。
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10
The URE2 gene product of Saccharomyces cerevisiae plays an important role in the cellular response to the nitrogen source and has homology to glutathione s-transferases.酿酒酵母的URE2基因产物在细胞对氮源的反应中起重要作用，并且与谷胱甘肽S-转移酶具有同源性。
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两种转录因子Gln3p和Nil1p利用相同的GATAAG位点来激活酿酒酵母GAP1的表达。

Two transcription factors, Gln3p and Nil1p, use the same GATAAG sites to activate the expression of GAP1 of Saccharomyces cerevisiae.

作者信息

Stanbrough M, Magasanik B

机构信息

Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.

出版信息

J Bacteriol. 1996 Apr;178(8):2465-8. doi: 10.1128/jb.178.8.2465-2468.1996.

DOI:10.1128/jb.178.8.2465-2468.1996
PMID:8636059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC177966/
Abstract

We present an analysis of the DNA region located upstream of GAP1, the structural gene for the general amino acid permease, which contains the sites required for activation of transcription of this gene in response to the nitrogen source of the growth medium. This gene is not expressed in media containing glutamine, and its transcription is activated in response to Gln3p in cells using glutamate as the source of nitrogen and by Nil1p in cells using urea as the source of nitrogen. We show that full response to both activators requires the presence of two GATAAG sites, as well as the presence of auxiliary sites located in the interval between 602 and 453 bp from the translational start site. The fact that both Gln3p and Nil1p utilize GATAAG sites to activate transcription is reflected in the high homology of the zinc finger regions of the two proteins.

摘要

我们对位于通用氨基酸通透酶结构基因GAP1上游的DNA区域进行了分析，该区域包含该基因响应生长培养基氮源而激活转录所需的位点。该基因在含有谷氨酰胺的培养基中不表达，在以谷氨酸为氮源的细胞中其转录由Gln3p激活，在以尿素为氮源的细胞中由Nil1p激活。我们表明，对两种激活剂的完全响应需要存在两个GATAAG位点，以及位于距翻译起始位点602至453 bp区间内的辅助位点。Gln3p和Nil1p都利用GATAAG位点激活转录这一事实反映在这两种蛋白质锌指区域的高度同源性上。