Fukatsu A, Sato N, Shimizu H
First Department of Internal Medicine, Gunma University School of Medicine, Japan.
Life Sci. 1996;58(25):2337-43. doi: 10.1016/0024-3205(96)00234-2.
To examine the effect of intensive aerobic exercise on the interaction between endocrine and immune systems, we studied in ten normal healthy male subjects the effect of a 50-mile walking race on blood concentration of hormones (insulin, GH, ACTH, cortisol, adrenaline, noradrenaline, and dopamine), ketone bodies, specific immunological functions (IgG, IgM, and PHA/Con A-induced lymphocyte blastformation test), and nonspecific immune (CH50, and neutrophil bactericidal functions). Neutrophil bactericidal activity was measured as chemiluminescences amplified by luciferin analog (CLA-DCL) and luminol (L-DCL). The race increased cortisol and ketone bodies, and decreased insulin, CLA-DCL, and L-DCL (all parameters; P < 0.01). However, other parameters were not significantly changed. There were significant negative correlations between changes of ketone bodies/cortisol and CLA/L-DCL (P < 0.05), however there was no significant correlations between changes of insulin and CLA/L-DCL. These data indicate that extensive aerobic exercise causes impaired neutrophil bactericidal function, probably due to the induced increases in both cortisol and ketone bodies. This impaired neutrophil function may cause the susceptibility to infection after an extensive exercise.
为研究高强度有氧运动对内分泌系统与免疫系统相互作用的影响，我们对10名正常健康男性受试者进行了研究，观察50英里步行比赛对血液中激素（胰岛素、生长激素、促肾上腺皮质激素、皮质醇、肾上腺素、去甲肾上腺素和多巴胺）、酮体、特定免疫功能（免疫球蛋白G、免疫球蛋白M以及PHA/刀豆蛋白A诱导的淋巴细胞增殖试验）和非特异性免疫（总补体活性以及中性粒细胞杀菌功能）浓度的影响。中性粒细胞杀菌活性通过荧光素类似物（CLA-DCL）和鲁米诺（L-DCL）放大的化学发光法进行测定。比赛使皮质醇和酮体增加，胰岛素、CLA-DCL和L-DCL降低（所有参数；P<0.01）。然而，其他参数没有显著变化。酮体/皮质醇的变化与CLA/L-DCL之间存在显著负相关（P<0.05），但胰岛素的变化与CLA/L-DCL之间没有显著相关性。这些数据表明，长时间有氧运动导致中性粒细胞杀菌功能受损，可能是由于皮质醇和酮体的诱导增加所致。这种中性粒细胞功能受损可能导致长时间运动后易发生感染。
