磁共振成像（MRI）检测小鼠大脑对光的反应：时间分辨及负性功能MRI变化

Huang W, Plyka I, Li H, Eisenstein E M, Volkow N D, Springer C S

Department of Chemistry, State University of New York, Stony Brook, 11794, USA.

Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):6037-42. doi: 10.1073/pnas.93.12.6037.

Using a 9.4 T MRI instrument, we have obtained images of the mouse brain response to photic stimulation during a period between deep anesthesia and the early stages of arousal. The large image enhancements we observe (often >30%) are consistent with literature results extrapolated to 9.4 T. However, there are also two unusual aspects to our findings. (i) The visual area of the brain responds only to changes in stimulus intensity, suggesting that we directly detect operations of the M visual system pathway. Such a channel has been observed in mice by invasive electrophysiology, and described in detail for primates. (ii) Along with the typical positive response in the area of the occipital portion of the brain containing the visual cortex, another area displays decreased signal intensity upon stimulation.

使用一台9.4 T的磁共振成像（MRI）仪器，我们获取了小鼠大脑在深度麻醉至苏醒早期对光刺激反应的图像。我们观察到的大幅图像增强（通常>30%）与外推至9.4 T的文献结果一致。然而，我们的发现还有两个不同寻常之处。（i）大脑的视觉区域仅对刺激强度的变化做出反应，这表明我们直接检测到了M视觉系统通路的运作。通过侵入性电生理学在小鼠中观察到了这样一个通道，并在灵长类动物中进行了详细描述。（ii）除了在包含视觉皮层的大脑枕叶区域出现典型的阳性反应外，另一个区域在受到刺激时信号强度降低。