Tzouvelekis L S, Tzelepi E, Mentis A F, Legakis N J
Dept. of Bacteriology, Hellenic Pasteur Institute, Athens, Greece.
Infection. 1995 Nov-Dec;23(6):384-7. doi: 10.1007/BF01713572.
Previous studies have shown that there is a high incidence of resistance to cephalosporins among enterobacteria isolated in Greek hospitals. This resistance is mainly due to either the derepression of chromosomal cephalosporinases or the acquisition of plasmids coding for SHV-5 type beta-lactamase. In the present study the activity of cefpirome against a number of enterobacteria (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Enterobacter aerogenes and Serratia marcescens) possessing the mechanisms mentioned above was examined. Cefpirome was found active against all the strains characterized by stable derepression of chromosomal class-C enzymes. The antibiotic was less potent against strains expressing SHV-5 type beta-lactamase due to its hydrolysis by the enzyme. Also cefpirome exhibited good activity against E. aerogenes strains with reduced susceptibility to imipenem. These in vitro data suggest that cefpirome might be useful in treating infections caused by these resistant microorganisms that are frequently encountered in Greek hospitals.
以往的研究表明，在希腊医院分离出的肠杆菌中，对头孢菌素耐药的发生率很高。这种耐药性主要是由于染色体头孢菌素酶的去阻遏作用，或者是获得了编码SHV-5型β-内酰胺酶的质粒。在本研究中，检测了头孢匹罗对一些具有上述机制的肠杆菌（大肠杆菌、肺炎克雷伯菌、阴沟肠杆菌、产气肠杆菌和粘质沙雷氏菌）的活性。发现头孢匹罗对所有以染色体C类酶稳定去阻遏为特征的菌株均有活性。由于该抗生素被SHV-5型β-内酰胺酶水解，因此对表达该酶的菌株效力较低。此外，头孢匹罗对亚胺培南敏感性降低的产气肠杆菌菌株也表现出良好的活性。这些体外数据表明，头孢匹罗可能有助于治疗希腊医院中经常遇到的由这些耐药微生物引起的感染。
