Kadletz Lorenz, Grasl Stefan, Perisanidis Christos, Grasl Matthäus C, Erovic Boban M
Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Department of Maxillofacial Surgery, University of Athens, Athens, Greece.
Eur Arch Otorhinolaryngol. 2019 Apr;276(4):1191-1196. doi: 10.1007/s00405-019-05319-6. Epub 2019 Feb 7.
Recently, there has been an increase in the number of reported Warthin's tumors, but few risk factors have been described for this benign tumor. Yet, smoking is the only evidently identified risk factor. Obesity and the metabolic syndrome are causally linked to or a risk factor for a variety of diseases. Therefore, we analyzed whether metabolic syndrome, including obesity, might influence the incidence of Warthin's tumors.
In this retrospective study, we evaluated 197 patients with Warthin's tumor. We assessed the tumor size, the body mass index (BMI), comorbidities related to the metabolic syndrome, and cigarette and alcohol consumption. Additionally, we evaluated several blood parameters and their influence.
Warthin's tumor patients had a significantly higher BMI in comparison to patients with other benign parotid gland tumors (29.1 versus 26.2, p < 0.0001). The rate of metabolic syndrome-associated comorbidities was higher in Warthin's tumor patients (62.4% versus 35.2%, p < 0.0001).
Our results might be the first step to recognize obesity and its consequences as a co-driver in the formation of Warthin's tumors. Nevertheless, further studies are requested to validate our results and to answer the question whether obesity or the metabolic syndrome are integrally linked to Warthin's tumors.
最近，沃辛瘤的报告数量有所增加，但针对这种良性肿瘤描述的风险因素很少。然而，吸烟是唯一明确确定的风险因素。肥胖和代谢综合征与多种疾病存在因果关系或为其风险因素。因此，我们分析了包括肥胖在内的代谢综合征是否可能影响沃辛瘤的发病率。
在这项回顾性研究中，我们评估了197例沃辛瘤患者。我们评估了肿瘤大小、体重指数（BMI）、与代谢综合征相关的合并症以及吸烟和饮酒情况。此外，我们评估了多项血液参数及其影响。
与其他腮腺良性肿瘤患者相比，沃辛瘤患者的BMI显著更高（29.1对26.2，p < 0.0001）。沃辛瘤患者中与代谢综合征相关的合并症发生率更高（62.4%对35.2%，p < 0.0001）。
我们的结果可能是将肥胖及其后果视为沃辛瘤形成的共同驱动因素的第一步。然而，需要进一步研究来验证我们的结果，并回答肥胖或代谢综合征是否与沃辛瘤存在内在联系的问题。
