Forsum U, Klareskog L, Peterson P A
Scand J Immunol. 1979;9(4):343-9. doi: 10.1111/j.1365-3083.1979.tb03172.x.
Ia-antigen-like molecules are expressed on cells within several different non-lymphoid tissues of the guinea-pig. In indirect immunofluorescence analyses anti-Ia-antigen antibodies stained epithelial cells lining the intestinal tract, the bile ducts, the respiratory tract and the urinary tract. The rabbit antibodies against Ia antigens also stained the cells of the parotid and the submandibular glands. Evidence was also obtained suggesting that the reticuloepithelial cells of the thymus, like the Kupffer cells of the liver, express Ia-antigen-like molecules. In several cases indirect immunoprecipitation analyses and SDS-polyacrylamide gel electrophoresis confirmed the immunofluorescence studies inasmuch as Ia-antigen-like subunits with apparent molecular weights of 26,000 and 34,000 could be isolated from the non-lymphoid organs.
豚鼠的几种不同非淋巴组织中的细胞表达Ia抗原样分子。在间接免疫荧光分析中，抗Ia抗原抗体对肠道、胆管、呼吸道和尿道的上皮细胞进行了染色。抗Ia抗原的兔抗体也对腮腺和下颌下腺的细胞进行了染色。还获得了证据表明，胸腺的网状上皮细胞与肝脏的库普弗细胞一样，表达Ia抗原样分子。在几种情况下，间接免疫沉淀分析和SDS-聚丙烯酰胺凝胶电泳证实了免疫荧光研究，因为可以从非淋巴器官中分离出表观分子量为26,000和34,000的Ia抗原样亚基。
