英国酒精性肝病模式的变化：与性别及自身免疫迹象的关系
Changing pattern of alcoholic liver disease in Great Britain: relation to sex and signs of autoimmunity.
作者信息
Krasner N, Davis M, Portmann B, Williams R
出版信息
Br Med J. 1977 Jun 11;1(6075):1497-1500. doi: 10.1136/bmj.1.6075.1497.
Abstract
A survey of 293 patients with alcoholic liver disease showed that women, particularly those aged under 45, had a significantly higher incidence of alcoholic hepatitis, with or without superimposed cirrhosis, than men. The long-term prognosis for both women who continued to drink and those who stopped drinking was worse than that for men. Autoantibodies were more common in women, which suggested that immune mechanisms may play a part in the pathogenesis and progression of alcoholic liver disease in women.
摘要
一项针对293例酒精性肝病患者的调查显示，女性，尤其是45岁以下的女性，无论是否合并肝硬化，酒精性肝炎的发病率均显著高于男性。继续饮酒和戒酒的女性的长期预后均比男性差。自身抗体在女性中更为常见，这表明免疫机制可能在女性酒精性肝病的发病机制和进展中起作用。
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