Ninomiya Y, Fukami Y, Yamazaki K, Beauchamp G K
Department of Oral Physiology, Asahi University School of Dentistry, Gifu, Japan.
Brain Res. 1996 Feb 5;708(1-2):153-8. doi: 10.1016/0006-8993(95)01218-4.
Inhibitory effects of amiloride on salt responses of the chorda tympani nerve and its temperature dependency were compared among three inbred strains of mice (C57BL, BALB and 129). In C57BL mice, lingual treatment with amiloride significantly suppressed responses to 0.1-1.0 M NaCl at two different temperatures, 24 +/- 2 degrees C and 12 +/- 2 degrees C. The magnitude of the amiloride-inhibited component of NaCl response was slightly larger at the higher temperature. In contrast, in BALB mice, amiloride suppression of NaCl responses was observed only at the lower temperature. No such suppression was exhibited by 129 mice at either temperature levels. These results suggest that there exist at least two different amiloride-sensitive receptor components for NaCl in mice: one is more sensitive to NaCl at the higher temperature, and the other is more sensitive at the lower temperature. It is hypothesized, C57BL mice possess the former (or both) component(s), whereas BALB mice have the latter one. The 129 strain may be lacking both components.
比较了氨氯地平对三种近交系小鼠（C57BL、BALB和129）鼓索神经盐反应的抑制作用及其温度依赖性。在C57BL小鼠中，用氨氯地平处理舌部在24±2℃和12±2℃这两个不同温度下均显著抑制了对0.1 - 1.0 M NaCl的反应。在较高温度下，氨氯地平抑制的NaCl反应成分的幅度略大。相比之下，在BALB小鼠中，仅在较低温度下观察到氨氯地平对NaCl反应的抑制。在两个温度水平下，129小鼠均未表现出这种抑制。这些结果表明，小鼠中至少存在两种不同的对氨氯地平敏感的NaCl受体成分：一种在较高温度下对NaCl更敏感，另一种在较低温度下更敏感。据推测，C57BL小鼠拥有前者（或两者）成分，而BALB小鼠拥有后者成分。129品系可能两种成分都缺乏。
