偏好氯化钠的新西兰黑/黑1新泽西小鼠和回避氯化钠的CBA/J小鼠对鼓索神经对氯化钠反应的氨氯地平抑制作用相似。
NaCl-preferring NZB/B1NJ mice and NaCl-avoiding CBA/J mice have similar amiloride inhibition of chorda tympani responses to NaCl.
作者信息
Ninomiya Y, Bachmanov A A, Yatabe A, Beauchamp G K
机构信息
Monell Chemical Senses Center, Philadelphia, PA 19104-3308, USA.
出版信息
Chem Senses. 1998 Aug;23(4):411-5. doi: 10.1093/chemse/23.4.411.
Abstract
Integrated chorda tympani nerve responses to NaCl were studied in two mouse strains, an NaCl-preferring NZB/B1NJ and an NaCl-avoiding CBA/J. The NaCl responses of both strains had similar magnitude and were suppressed by amiloride to a similar extent. This suggests that peripheral gustatory responsiveness to NaCl is not the only mechanism underlying mouse strain variation in NaCl acceptance.
摘要
在两种小鼠品系中研究了鼓索神经对氯化钠的综合反应，一种是偏好氯化钠的NZB/B1NJ品系，另一种是回避氯化钠的CBA/J品系。两种品系对氯化钠的反应幅度相似，并且被氨氯吡咪抑制的程度也相似。这表明，外周味觉对氯化钠的反应性不是小鼠品系在氯化钠接受度方面存在差异的唯一潜在机制。
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