Vitek C R, Breiman R F, Ksiazek T G, Rollin P E, McLaughlin J C, Umland E T, Nolte K B, Loera A, Sewell C M, Peters C J
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Clin Infect Dis. 1996 May;22(5):824-6. doi: 10.1093/clinids/22.5.824.
Unusual, primarily pulmonary, manifestations of hantaviral illness occurring in the southwestern United States raised the possibility of person-to-person transmission of a recently recognized hantavirus, Sin Nombre virus. To determine whether such transmission had occurred among health care workers (HCWs) exposed to patients with confirmed hantavirus pulmonary syndrome, we evaluated HCWs who had cared for patients with hantavirus pulmonary syndrome or who had processed specimens from these patients. Information about exposure to these patients and about recent illnesses was obtained via a standardized questionnaire. Serum specimens were tested for IgM and IgG antibodies to hantaviruses with use of ELISAs. Of the 396 HCWs, 266 (67%) reported that they had been exposed to patients with hantavirus pulmonary syndrome or to their body fluids or that they had processed laboratory specimens from these patients. Although 108 (27%) of the HCWs reported fever, myalgias, or respiratory illnesses during the 3 months before the serum specimens were obtained, hantavirus antibodies were not detected in any HCW. These data suggest that person-to-person transmission of Sin Nombre virus is unlikely to occur in health care settings.
在美国西南部出现的汉坦病毒病的异常、主要为肺部的表现，引发了一种最近确认的汉坦病毒——辛诺柏病毒人际传播的可能性。为了确定在接触确诊汉坦病毒肺综合征患者的医护人员中是否发生了这种传播，我们评估了曾护理过汉坦病毒肺综合征患者或处理过这些患者标本的医护人员。通过标准化问卷获取了有关接触这些患者以及近期疾病的信息。使用酶联免疫吸附测定法检测血清标本中针对汉坦病毒的IgM和IgG抗体。在396名医护人员中，266名（67%）报告称他们曾接触过汉坦病毒肺综合征患者或其体液，或者处理过这些患者的实验室标本。尽管108名（27%）医护人员报告在获取血清标本前的3个月内出现发热、肌痛或呼吸道疾病，但在任何医护人员中均未检测到汉坦病毒抗体。这些数据表明，辛诺柏病毒在医疗环境中不太可能发生人际传播。
