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Antibiotic exposure and its relationship to postantibiotic effect and bactericidal activity: constant versus exponentially decreasing tobramycin concentrations against Pseudomonas aeruginosa.抗生素暴露及其与抗生素后效应和杀菌活性的关系：针对铜绿假单胞菌的恒定与指数递减妥布霉素浓度
Antimicrob Agents Chemother. 1997 Aug;41(8):1808-11. doi: 10.1128/AAC.41.8.1808.
2
Impact of pharmacokinetics on the postantibiotic effect exhibited by Pseudomonas aeruginosa following tobramycin exposure: application of an in-vitro model.妥布霉素暴露后铜绿假单胞菌的药代动力学对其抗生素后效应的影响：体外模型的应用
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Chemotherapy. 1991;37(2):114-21. doi: 10.1159/000238842.
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Changes in MIC alter responses of Pseudomonas aeruginosa to tobramycin exposure.最低抑菌浓度（MIC）的变化会改变铜绿假单胞菌对妥布霉素暴露的反应。
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Kill kinetics and regrowth patterns of Pseudomonas aeruginosa exposed to concentration-time profiles of tobramycin simulating in vivo infusion and bolus dosing.暴露于模拟体内输注和大剂量给药的妥布霉素浓度-时间曲线下的铜绿假单胞菌的杀灭动力学和再生长模式。
Antimicrob Agents Chemother. 1996 May;40(5):1321-4. doi: 10.1128/AAC.40.5.1321.
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The influence of postantibiotic effects and postantibiotic effects of sub-inhibitory concentrations of quinolones and aminoglycosides on phospholipase C of Pseudomonas aeruginosa.喹诺酮类和氨基糖苷类亚抑菌浓度的抗生素后效应及抗生素后效应对铜绿假单胞菌磷脂酶C的影响。
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引用本文的文献

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Achieving an optimal outcome in the treatment of infections. The role of clinical pharmacokinetics and pharmacodynamics of antimicrobials.实现感染治疗的最佳效果。抗菌药物临床药代动力学和药效学的作用。
Clin Pharmacokinet. 1999 Jul;37(1):1-16. doi: 10.2165/00003088-199937010-00001.

本文引用的文献

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The fractional maximal effect method: a new way to characterize the effect of antibiotic combinations and other nonlinear pharmacodynamic interactions.分数最大效应法：一种表征抗生素联合用药及其他非线性药效学相互作用效果的新方法。
Antimicrob Agents Chemother. 1993 Mar;37(3):523-31. doi: 10.1128/AAC.37.3.523.
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Pharmacodynamic modeling of bacterial kinetics: beta-lactam antibiotics against Escherichia coli.细菌动力学的药效学建模：β-内酰胺类抗生素对大肠杆菌的作用
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Inhibition of terfenadine metabolism. Pharmacokinetic and pharmacodynamic consequences.特非那定代谢的抑制作用。药代动力学和药效学后果。
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Pharmacokinetic contributions to postantibiotic effects. Focus on aminoglycosides.药代动力学对抗生素后效应的影响。重点关注氨基糖苷类药物。
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Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins.在确定广谱头孢菌素给药方案时药代动力学与药效学之间的相互关系。
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Impact of dosing intervals on activity of gentamicin and ticarcillin against Pseudomonas aeruginosa in granulocytopenic mice.给药间隔对庆大霉素和替卡西林在粒细胞减少小鼠中抗铜绿假单胞菌活性的影响。
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Postantibiotic suppression of bacterial growth.抗生素后细菌生长抑制
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Microbial kinetics of beta-lactam antibiotics against Escherichia coli.β-内酰胺类抗生素对大肠杆菌的微生物动力学
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Microbial pharmacodynamics of piperacillin in neutropenic mice of systematic infection due to Pseudomonas aeruginosa.
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Correlation of antimicrobial pharmacokinetic parameters with therapeutic efficacy in an animal model.抗菌药物药代动力学参数与动物模型治疗效果的相关性。
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抗生素暴露及其与抗生素后效应和杀菌活性的关系：针对铜绿假单胞菌的恒定与指数递减妥布霉素浓度

Antibiotic exposure and its relationship to postantibiotic effect and bactericidal activity: constant versus exponentially decreasing tobramycin concentrations against Pseudomonas aeruginosa.

作者信息

Li R C, Zhu Z Y, Lee S W, Raymond K, Ling J M, Cheng A F

机构信息

Department of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin.

出版信息

Antimicrob Agents Chemother. 1997 Aug;41(8):1808-11. doi: 10.1128/AAC.41.8.1808.

DOI:10.1128/AAC.41.8.1808
PMID:9257767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC164011/
Abstract

In vitro postantibiotic effects (PAEs) exhibited by a standard strain of Pseudomonas aeruginosa following exposure to tobramycin at constant concentrations were compared to those at exponentially decreasing concentrations. Exposure to a constant concentration showed more extensive bacterial killing and resulted in longer PAEs at comparable areas under the concentration-time curves above the MIC. This phenomenon suggests a significant contribution of pharmacokinetics to antimicrobial pharmacodynamics.

摘要

将铜绿假单胞菌标准菌株在恒定浓度下暴露于妥布霉素后所表现出的体外抗生素后效应（PAEs）与在指数下降浓度下的效应进行比较。暴露于恒定浓度显示出更广泛的细菌杀灭作用，并且在高于最低抑菌浓度（MIC）的浓度-时间曲线下的可比区域产生更长的PAEs。这一现象表明药代动力学对抗菌药效学有重大贡献。