抗生素暴露及其与抗生素后效应和杀菌活性的关系：针对铜绿假单胞菌的恒定与指数递减妥布霉素浓度
Antibiotic exposure and its relationship to postantibiotic effect and bactericidal activity: constant versus exponentially decreasing tobramycin concentrations against Pseudomonas aeruginosa.
作者信息
Li R C, Zhu Z Y, Lee S W, Raymond K, Ling J M, Cheng A F
机构信息
Department of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin.
出版信息
Antimicrob Agents Chemother. 1997 Aug;41(8):1808-11. doi: 10.1128/AAC.41.8.1808.
Abstract
In vitro postantibiotic effects (PAEs) exhibited by a standard strain of Pseudomonas aeruginosa following exposure to tobramycin at constant concentrations were compared to those at exponentially decreasing concentrations. Exposure to a constant concentration showed more extensive bacterial killing and resulted in longer PAEs at comparable areas under the concentration-time curves above the MIC. This phenomenon suggests a significant contribution of pharmacokinetics to antimicrobial pharmacodynamics.
摘要
将铜绿假单胞菌标准菌株在恒定浓度下暴露于妥布霉素后所表现出的体外抗生素后效应（PAEs）与在指数下降浓度下的效应进行比较。暴露于恒定浓度显示出更广泛的细菌杀灭作用，并且在高于最低抑菌浓度（MIC）的浓度-时间曲线下的可比区域产生更长的PAEs。这一现象表明药代动力学对抗菌药效学有重大贡献。
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