Dlugosz L, Belanger K, Hellenbrand K, Holford T R, Leaderer B, Bracken M B
Department of Epidemiology, Yale University School of Medicine, New Haven, CT 06520-8034, USA.
Epidemiology. 1996 May;7(3):250-5. doi: 10.1097/00001648-199605000-00006.
We investigated the relation between caffeine beverage consumption and spontaneous abortion in 2,967 pregnant women planning to deliver at Yale-New Haven Hospital in 1988-1992. We evaluated coffee, tea, and soda drinking in the first month of pregnancy in interviews before the end of the sixteenth week of gestation. We obtained information on 98.2% of the pregnancies (including 2,714 singleton livebirths and 135 spontaneous abortions). As compared with abstention from caffeine beverages (coffee, tea, and soda), the adjusted odds ratios for spontaneous abortion associated with consumption of 1-150, 151-300, and > 300 mg caffeine daily were 0.81 [95% confidence interval (CI)) = 0.54-1.20], 0.89 (95% CI = 0.48-1.64), and 1.75 (95% CI = 0.88-3.47), respectively. Drinking > or = 3 cups of tea or coffee was associated with elevated risks of spontaneous abortion (adjusted odds ratio = 2.33, 95% CI = 0.92-5.85; and adjusted odds ratio = 2.63, 95% CI = 1.29-5.34, respectively). These results, if replicated, suggest that some ingredient (or correlate) of tea or coffee may account for some of the observed association of caffeine with spontaneous abortion. In this study, caffeine consumption is more strongly related to spontaneous abortion than alcohol or cigarette use in early pregnancy.
我们调查了1988年至1992年计划在耶鲁 - 纽黑文医院分娩的2967名孕妇中咖啡因饮料摄入量与自然流产之间的关系。在妊娠第16周结束前的访谈中，我们评估了怀孕第一个月时咖啡、茶和汽水的饮用情况。我们获取了98.2%的妊娠信息（包括2714例单胎活产和135例自然流产）。与不饮用咖啡因饮料（咖啡、茶和汽水）相比，每日摄入1 - 150毫克、151 - 300毫克和> 300毫克咖啡因与自然流产相关的校正比值比分别为0.81 [95%置信区间（CI）= 0.54 - 1.20]、0.89（95% CI = 0.48 - 1.64）和1.75（95% CI = 0.88 - 3.47）。饮用≥3杯茶或咖啡与自然流产风险升高相关（校正比值比分别为2.33，95% CI = 0.92 - 5.85；以及校正比值比为2.63，95% CI = 1.29 - 5.34）。这些结果若能得到重复验证，则表明茶或咖啡中的某些成分（或相关因素）可能是观察到的咖啡因与自然流产之间关联的部分原因。在本研究中，孕期早期咖啡因摄入量与自然流产的关联比酒精或吸烟更强。
