Jenkins D J, Gassull M A, Leeds A R, Metz G, Dilawari J B, Slavin B, Blendis L M
Gastroenterology. 1977 Aug;73(2):215-7.
The dumping syndrome is a very troublesome problem to some patients after gastric surgery. Gel-forming carbohydrates have recently been used to modify glucose absorption. The addition of 14.5 g of pectin to a 50-g oral glucose load prevented the occurrence of hypoglycemic symptoms and maintained the blood glucose levels above control values by 64% at 90 min (P less than 0.002) and 46% at 120 min (P less than 0.01) in postgastric surgery patients whose 120-min values after 50 g of glucose alone had fallen below 50 mg per 100 ml (2.8 mmoles per liter). Breath H2 production, used as an index of bacterial fermentation of glucose, was abolished or reduced by pectin in all 5 cases in which this had previously occurred. A trial of 10 g of pectin per day prevented recurrent postprandial hypoglycemic attacks in the most severely affected individual. Pectin and perhaps other unabsorbable polysaccharides are likely to prove useful in the treatment of abnormal carbohydrate absorption after gastric surgery.
倾倒综合征对一些胃手术后的患者来说是个非常棘手的问题。凝胶形成性碳水化合物最近已被用于改善葡萄糖吸收。对于胃手术后的患者，在50克口服葡萄糖负荷中添加14.5克果胶可预防低血糖症状的发生，并使血糖水平在90分钟时比对照值高64%（P<0.002），在120分钟时比对照值高46%（P<0.01），这些患者在单独服用50克葡萄糖后的120分钟值已降至每100毫升低于50毫克（每升2.8毫摩尔）。在之前所有出现这种情况的5例患者中，用作葡萄糖细菌发酵指标的呼气氢气产生被果胶消除或减少。对最严重受影响的个体进行的一项每天服用10克果胶的试验预防了餐后复发性低血糖发作。果胶以及或许其他不可吸收的多糖可能在治疗胃手术后异常的碳水化合物吸收方面被证明是有用的。
