Chien A J, Dunner D L
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, USA.
J Psychiatr Res. 1996 Jan-Feb;30(1):21-7. doi: 10.1016/0022-3956(95)00041-0.
The goal of our study was to examine the stability over time of the personality measures defined by Cloninger's Tridimensional Personality Questionnaire (TPQ) in patients with major depression. We conducted a retrospective chart review of 63 outpatients who had participated in one of three double-blind antidepressant trials. All subjects had completed the TPQ upon entry and upon termination of the 12-week trials. Statistically significant decrements in harm avoidance scores were observed in those subjects whose depression improved, regardless of gender or duration of presenting depressive episode. No significant changes were observed in the other two dimensions (novelty seeking and reward dependence). Nonresponders as a group had no statistically significant decreases in any TPQ dimension or subscales. While novelty seeking and reward dependence remain relatively independent of mood, harm avoidance appears to be a measure which is elevated during depressive states and which changes with improvement of depression. These findings are consistent with those of other investigators.
我们研究的目的是检验由克隆宁格三因素人格问卷（TPQ）定义的人格测量指标在重度抑郁症患者中的随时间稳定性。我们对63名曾参与三项双盲抗抑郁试验之一的门诊患者进行了回顾性病历审查。所有受试者在进入试验时以及在12周试验结束时均完成了TPQ。在抑郁症有所改善的受试者中，无论性别或当前抑郁发作的持续时间如何，均观察到回避伤害得分有统计学意义的下降。在其他两个维度（寻求新奇和奖赏依赖）上未观察到显著变化。作为一个群体，无反应者在任何TPQ维度或子量表上均无统计学意义的下降。虽然寻求新奇和奖赏依赖相对独立于情绪，但回避伤害似乎是一种在抑郁状态时升高且随抑郁改善而变化的测量指标。这些发现与其他研究者的发现一致。
