瑞典助产士的轮班工作、一氧化二氮暴露与自然流产
Shift work, nitrous oxide exposure, and spontaneous abortion among Swedish midwives.
作者信息
Axelsson G, Ahlborg G, Bodin L
机构信息
Department of Environmental Medicine, Göteborg University, Sweden.
出版信息
Occup Environ Med. 1996 Jun;53(6):374-8. doi: 10.1136/oem.53.6.374.
OBJECTIVES
To study the relation between irregular work hours, nitrous oxide (N2O) exposure, and the risk of spontaneous abortion.
METHODS
All 3985 female members of the Swedish Midwives Association in 1989, born in 1940 or later, received a questionnaire on exposure before and during all of their pregnancies. Questions on work conditions covered occupation, extent of employment, workplace, work schedules, use of anaesthetics, and work load. The association between exposure variables and spontaneous abortion was analysed by logistic regression models.
RESULTS
Night work and three shift schedules among midwives showed increased odds ratios (ORs) (95% confidence intervals (95% CI)) 1.63 (0.95-2.81) and 1.49 (0.86-2.59), respectively. The ORs of late spontaneous abortions (after the 12th week of pregnancy) was increased for night work 3.33 (1.13-9.87). Use of N2O (> 50% of the deliveries) was not associated with increased risk of spontaneous abortion OR 0.95 (0.62-1.47). Frequent or permanent shortage of staff was related to an increased risk of spontaneous abortions before the 13th week of pregnancy.
CONCLUSIONS
The results support the hypothesis that night work and high work load increase the risk of spontaneous abortion.
目的
研究不规律工作时间、一氧化二氮（N₂O）暴露与自然流产风险之间的关系。
方法
1989年瑞典助产士协会的所有3985名女性成员，出生于1940年或之后，均收到一份关于其所有孕期之前及孕期期间暴露情况的问卷。工作条件方面的问题涵盖职业、就业范围、工作场所、工作时间表、麻醉剂使用情况及工作量。通过逻辑回归模型分析暴露变量与自然流产之间的关联。
结果
助产士中的夜班工作和三种轮班制显示比值比（OR）升高（95%置信区间（95%CI）），分别为1.63（0.95 - 2.81）和1.49（0.86 - 2.59）。晚期自然流产（妊娠12周后）的OR因夜班工作而升高，为3.33（1.13 - 9.87）。使用N₂O（超过50%的分娩）与自然流产风险增加无关，OR为0.95（0.62 - 1.47）。频繁或长期人员短缺与妊娠13周前自然流产风险增加有关。
结论
结果支持夜班工作和高工作量会增加自然流产风险这一假设。
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