职业性父亲接触苯与自然流产风险
Occupational paternal exposure to benzene and risk of spontaneous abortion.
作者信息
Strücker I, Mandereau L, Aubert-Berleur M P, Déplan F, Paris A, Richard A, Hémon D
机构信息
Unité de Recherches Epidémiologiques et Statistiques sur l'Environnement et la Santé, INSERM U 170, Villejuif, France.
出版信息
Occup Environ Med. 1994 Jul;51(7):475-8. doi: 10.1136/oem.51.7.475.
OBJECTIVE
The purpose of this study was to evaluate the risk of spontaneous abortion among the wives of male workers occupationally exposed to benzene.
METHODS
The wives of 823 men working in two chemical plants at the time of the study were asked to complete a questionnaire describing their pregnancies. The analysis of the 1739 pregnancies that ended in a spontaneous abortion or a birth is presented. The firms' payroll records provided all workers' employment history, including dates. Benzene exposure, graded at two levels (< 5, > or = 5 ppm), was determined for every job, so that benzene exposure for each worker's entire professional life (at these companies) could be assessed. This information was linked to the dates of the pregnancies reported in the questionnaires to enable the exposure status of each pregnancy to be defined (1270 non-exposed and 274 exposed). The frequency of spontaneous abortion, defined as the number of spontaneous abortions divided by the total of spontaneous abortions and births was evaluated.
RESULTS
When adjusted for tobacco consumption, mother's age and pregnancy order, the odds ratio of the association between paternal exposure to approximately 5 ppm of benzene and the risk of spontaneous abortion was close to and statistically not different from unity (OR = 1.1; 95% CI (0.7-1.8).
CONCLUSION
In this study paternal exposure to benzene did not increase the risk of spontaneous abortion.
目的
本研究旨在评估职业性接触苯的男性工人妻子发生自然流产的风险。
方法
研究期间，对两家化工厂的823名男性工人的妻子进行问卷调查，了解她们的妊娠情况。对1739例以自然流产或分娩告终的妊娠情况进行分析。公司工资记录提供了所有工人的就业历史，包括日期。对每份工作的苯接触情况分为两个等级（<5 ppm、≥5 ppm）进行测定，从而能够评估每名工人在这些公司整个职业生涯中的苯接触情况。将这些信息与问卷中报告的妊娠日期相关联，以确定每次妊娠的接触状况（1270例未接触和274例接触）。评估自然流产频率，定义为自然流产数除以自然流产和分娩总数。
结果
在对吸烟、母亲年龄和妊娠顺序进行校正后，父亲接触约5 ppm苯与自然流产风险之间关联的优势比接近1且在统计学上无差异（优势比=1.1；95%可信区间（0.7 - 1.8））。
结论
在本研究中，父亲接触苯并未增加自然流产风险。
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